Clinical Research
Copyright ©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Nov 28, 2007; 13(44): 5918-5925
Published online Nov 28, 2007. doi: 10.3748/wjg.v13.i44.5918
Table 1 Systemic hemodynamic parameters, KICG values and splanchnic circulatory parameters before LDLT
ParametersHealthy individuals n = 16Group I n = 25Group II n = 5
Systemic hemodynamics
CO (L/min)5.83 ± 1.526.87 ± 0.97a7.36 ± 1.07e
CI (L/min per m2)3.22 ± 0.714.10 ± 0.71b4.56 ± 0.58e
BV (L)3.40 ± 0.964.09 ± 0.51a4.40 ± 0.45e
CO/BV (/min)1.74 ± 0.281.69 ± 0.211.69 ± 0.28
MTT (s)16.1 ± 2.316.5 ± 1.516.5 ± 1.2
HR (beat/min)64.3 ± 9.977.9 ± 12.6b77.6 ± 9.8e
MAP (mmHg)89.3 ± 11.868.9 ± 6.5d70.8 ± 11.2e
TPR (dyne/s5 per cm)1275.1 ± 228.3818.9 ± 166.7d785.3 ± 187.4e
ICG clearance test
KICG0.227 ± 0.0760.037 ± 0.017d0.056 ± 0.038e
Splanchnic circulation
Portal vein
PVFVo (mL/min)1482.1 ± 335.6327.3 ± 416.9d435.6 ± 592.6e
PVFVe (cm/s)45.1 ± 8.17.9 ± 12.8d10.5 ± 13.8f
Hepatic artery
HAPI0.95 ± 0.111.06 ± 0.28a1.16 ± 0.21e
HARI0.93 ± 0.261.04 ± 0.23a1.10 ± 0.10e
Table 2 Clinical profiles before, during and after LDLT
Clinical profileGroup I(n = 25)Group II(n = 5)P valuea
Before LDLT
Age51.8 ± 9.858.6 ± 3.5NS
Body surface area (m2)1.69 ± 0.181.61 ± 0.12NS
Child-Pugh score (points)9.2 ± 2.310.8 ± 2.2NS
Model for end-stage liver disease score (points)17.6 ± 6.717.4 ± 7.1NS
During LDLT
Native liver weight (g)857.0 ± 227.5946.0 ± 376.2NS
Portal venous pressure before removal of native liver (mmHg)21.5 ± 4.724.6 ± 7.1NS
Cold ischemic time (min)163.7 ± 79.0139.6 ± 52.6NS
Warm ischemic time (min)55.1 ± 16.745.8 ± 12.7NS
Anhepatic phase (min)209.2 ± 104.9184.4 ± 177.6NS
Operative time (min)899.4 ± 126.7933.4 ± 131.0NS
Blood loss (mL)22515.7 ± 14200.522788.6 ± 19247.8NS
Graft weight (g)687.8 ± 124.6632.0 ± 72.9NS
Graft-recipient weight ratio1.09 ± 0.211.23 ± 0.37NS
After LDLT
Intensive care unit stay (d)5.1 ± 1.935.6 ± 15.7< 0.005
%SLV based on CT volumetry
2 wk after LDLT1.14 ± 0.221.07 ± 0.09NS
4 wk after LDLT1.05 ± 0.151.17 ± 0.16NS
LHL15 based on 99mTc-GSA liver scintigraphy
2 wk after LDLT0.935 ± 0.0260.846 ± 0.061< 0.005
4 wk after LDLT0.941 ± 0.0170.751 ± 0.034< 0.005
Histopathological fraft parenchymal damage score (points)
Within 4 wk after LDLT3.9 ± 1.410.6 ± 1.3< 0.005
Table 3 Statistical differences in post-operative temporal changes of systemic hemodynamic parameters, KICG values and splanchnic circulatory parameters
ParametersStatistical temporal differences after LDLT between Groups I and II P value1
Systemic hemodynamics
CO (L/min)0.2321
CI (L/min per m2)0.5037
BV (L)0.3420
CO/BV (/min)0.0426a
MTT (s)0.0023b
HR (beat/min)0.0701
MAP (mmHg)0.2453
TPR (dyne/s5 per cm)0.8859
ICG clearance test
KICG0.0001d
Splanchnic circulation
Portal vein
PVFVo (mL/min)0.0113a
PVFVe (cm/s)0.0171a
Hepatic artery
HAPI0.2504
HARI0.4261

  • Citation: Hori T, Yagi S, Iida T, Taniguchi K, Yamagiwa K, Yamamoto C, Hasegawa T, Yamakado K, Kato T, Saito K, Wang L, Torii M, Hori Y, Takeda K, Maruyama K, Uemoto S. Stability of cirrhotic systemic hemodynamics ensures sufficient splanchnic blood flow after living-donor liver transplantation in adult recipients with liver cirrhosis. World J Gastroenterol 2007; 13(44): 5918-5925
  • URL: https://www.wjgnet.com/1007-9327/full/v13/i44/5918.htm
  • DOI: https://dx.doi.org/10.3748/wjg.v13.i44.5918