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©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Nov 28, 2007; 13(44): 5918-5925
Published online Nov 28, 2007. doi: 10.3748/wjg.v13.i44.5918
Published online Nov 28, 2007. doi: 10.3748/wjg.v13.i44.5918
Parameters | Healthy individuals n = 16 | Group I n = 25 | Group II n = 5 |
Systemic hemodynamics | |||
CO (L/min) | 5.83 ± 1.52 | 6.87 ± 0.97a | 7.36 ± 1.07e |
CI (L/min per m2) | 3.22 ± 0.71 | 4.10 ± 0.71b | 4.56 ± 0.58e |
BV (L) | 3.40 ± 0.96 | 4.09 ± 0.51a | 4.40 ± 0.45e |
CO/BV (/min) | 1.74 ± 0.28 | 1.69 ± 0.21 | 1.69 ± 0.28 |
MTT (s) | 16.1 ± 2.3 | 16.5 ± 1.5 | 16.5 ± 1.2 |
HR (beat/min) | 64.3 ± 9.9 | 77.9 ± 12.6b | 77.6 ± 9.8e |
MAP (mmHg) | 89.3 ± 11.8 | 68.9 ± 6.5d | 70.8 ± 11.2e |
TPR (dyne/s5 per cm) | 1275.1 ± 228.3 | 818.9 ± 166.7d | 785.3 ± 187.4e |
ICG clearance test | |||
KICG | 0.227 ± 0.076 | 0.037 ± 0.017d | 0.056 ± 0.038e |
Splanchnic circulation | |||
Portal vein | |||
PVFVo (mL/min) | 1482.1 ± 335.6 | 327.3 ± 416.9d | 435.6 ± 592.6e |
PVFVe (cm/s) | 45.1 ± 8.1 | 7.9 ± 12.8d | 10.5 ± 13.8f |
Hepatic artery | |||
HAPI | 0.95 ± 0.11 | 1.06 ± 0.28a | 1.16 ± 0.21e |
HARI | 0.93 ± 0.26 | 1.04 ± 0.23a | 1.10 ± 0.10e |
Clinical profile | Group I(n = 25) | Group II(n = 5) | P valuea |
Before LDLT | |||
Age | 51.8 ± 9.8 | 58.6 ± 3.5 | NS |
Body surface area (m2) | 1.69 ± 0.18 | 1.61 ± 0.12 | NS |
Child-Pugh score (points) | 9.2 ± 2.3 | 10.8 ± 2.2 | NS |
Model for end-stage liver disease score (points) | 17.6 ± 6.7 | 17.4 ± 7.1 | NS |
During LDLT | |||
Native liver weight (g) | 857.0 ± 227.5 | 946.0 ± 376.2 | NS |
Portal venous pressure before removal of native liver (mmHg) | 21.5 ± 4.7 | 24.6 ± 7.1 | NS |
Cold ischemic time (min) | 163.7 ± 79.0 | 139.6 ± 52.6 | NS |
Warm ischemic time (min) | 55.1 ± 16.7 | 45.8 ± 12.7 | NS |
Anhepatic phase (min) | 209.2 ± 104.9 | 184.4 ± 177.6 | NS |
Operative time (min) | 899.4 ± 126.7 | 933.4 ± 131.0 | NS |
Blood loss (mL) | 22515.7 ± 14200.5 | 22788.6 ± 19247.8 | NS |
Graft weight (g) | 687.8 ± 124.6 | 632.0 ± 72.9 | NS |
Graft-recipient weight ratio | 1.09 ± 0.21 | 1.23 ± 0.37 | NS |
After LDLT | |||
Intensive care unit stay (d) | 5.1 ± 1.9 | 35.6 ± 15.7 | < 0.005 |
%SLV based on CT volumetry | |||
2 wk after LDLT | 1.14 ± 0.22 | 1.07 ± 0.09 | NS |
4 wk after LDLT | 1.05 ± 0.15 | 1.17 ± 0.16 | NS |
LHL15 based on 99mTc-GSA liver scintigraphy | |||
2 wk after LDLT | 0.935 ± 0.026 | 0.846 ± 0.061 | < 0.005 |
4 wk after LDLT | 0.941 ± 0.017 | 0.751 ± 0.034 | < 0.005 |
Histopathological fraft parenchymal damage score (points) | |||
Within 4 wk after LDLT | 3.9 ± 1.4 | 10.6 ± 1.3 | < 0.005 |
Parameters | Statistical temporal differences after LDLT between Groups I and II P value1 |
Systemic hemodynamics | |
CO (L/min) | 0.2321 |
CI (L/min per m2) | 0.5037 |
BV (L) | 0.3420 |
CO/BV (/min) | 0.0426a |
MTT (s) | 0.0023b |
HR (beat/min) | 0.0701 |
MAP (mmHg) | 0.2453 |
TPR (dyne/s5 per cm) | 0.8859 |
ICG clearance test | |
KICG | 0.0001d |
Splanchnic circulation | |
Portal vein | |
PVFVo (mL/min) | 0.0113a |
PVFVe (cm/s) | 0.0171a |
Hepatic artery | |
HAPI | 0.2504 |
HARI | 0.4261 |
- Citation: Hori T, Yagi S, Iida T, Taniguchi K, Yamagiwa K, Yamamoto C, Hasegawa T, Yamakado K, Kato T, Saito K, Wang L, Torii M, Hori Y, Takeda K, Maruyama K, Uemoto S. Stability of cirrhotic systemic hemodynamics ensures sufficient splanchnic blood flow after living-donor liver transplantation in adult recipients with liver cirrhosis. World J Gastroenterol 2007; 13(44): 5918-5925
- URL: https://www.wjgnet.com/1007-9327/full/v13/i44/5918.htm
- DOI: https://dx.doi.org/10.3748/wjg.v13.i44.5918