Copyright
©2007 Baishideng Publishing Group Inc.
World J Gastroenterol. Nov 21, 2007; 13(43): 5725-5730
Published online Nov 21, 2007. doi: 10.3748/wjg.v13.i43.5725
Published online Nov 21, 2007. doi: 10.3748/wjg.v13.i43.5725
Controls n (%) | Colorectal cancer n (%) | Colon cancer n (%) | Rectal cancer n (%) | |
All of the subjects | 439 (100.0) | 315 (100.0) | 105 (100.0) | 210 (100.0) |
Gender | ||||
Males | 223 (50.8) | 190 (60.3) | 65 (61.9) | 125 (59.5) |
Females | 216 (49.2) | 125 (39.7) | 40 (38.1) | 85 (40.5) |
χ2MH (P) | 6.70 (0.010) | 4.19 (0.041) | 4.34 (0.037) | |
Age (yr) | ||||
< 40 | 42 (9.6) | 44 (14.0) | 14 (13.3) | 30 (14.3) |
40-49 | 75 (17.1) | 54 (17.1) | 15 (14.3) | 39 (18.6) |
50-59 | 150 (34.2) | 88 (27.9) | 30 (28.6) | 58 (27.6) |
60-69 | 131 (29.8) | 85 (29.0) | 26 (24.8) | 59 (28.1) |
> 70 | 41 (9.3) | 44 (14.0) | 20 (19.1) | 24 (11.4) |
χ2MH (P) | 9.37 (0.053) | 10.23 (0.037) | 5.69 (0.224) | |
Mean age ± SD | 55.7 ± 11.0 | 55.3 ± 12.7 | 56.4 ± 13.4 | 54.7 ± 12.3 |
P (t test) | 0.6172 | 0.6325 | 0.3159 | |
Smoking status | ||||
Nonsmoker | 284 (64.7) | 176 (55.9) | 61 (58.1) | 115 (54.8) |
Courrent and former | 155 (35.3) | 139 (44.1) | 44 (41.9) | 95 (45.2) |
χ2MH (P) | 5.99 (0.014) | 1.59 (0.208) | 5.91 (0.015) | |
Alcohol status | ||||
Nondrinker | 327 (74.5) | 176 (55.9) | 65 (61.9) | 120 (57.1) |
Current and former | 112 (25.5) | 139 (44.1) | 50 (38.1) | 90 (42.9) |
χ2MH (P) | 28.58 (0.000) | 14.19 (0.000) | 19.90 (0.000) | |
CYP 2E1 genotypes1 | ||||
c1/c1 | 266 (61.4) | 185 (59.1) | 63 (60.6) | 122 (58.4) |
c1/c2 | 154 (35.6) | 106 (33.9) | 35 (33.7) | 71 (34.0) |
c2/c2 | 13 (3.0) | 22 (7.0) | 6 (5.8) | 16 (7.7) |
χ2MH (P) | 6.58 (0.037) | 1.91 (0.385) | 7.07 (0.029) |
Genotype | Cases (n) | Controls (n) | OR1 (95% CI) | OR2 (95% CI) | |
Colorectal cancer | |||||
c1/c1 | 185 | 266 | 1.00 | 1.00 | |
c1/c2 | 106 | 154 | 0.99 (0.72-1.35) | 0.99 (0.72-1.35) | |
c2/c2 | 22 | 13 | 1.54 (1.07-2.19) | 1.55 (1.08-2.22) | |
Colon Cancer | |||||
c1/c1 | 63 | 266 | 1.00 | 1.00 | |
c1/c2 | 35 | 154 | 0.96 (0.61-1.52) | 0.95 (0.60-1.51) | |
c2/c2 | 6 | 13 | 1.36 (0.82-2.25) | 1.40 (0.84-2.33) | |
Rectal cancer | |||||
c1/c1 | 122 | 266 | 1.00 | 1.00 | |
c1/c2 | 71 | 154 | 1.01 (0.71-1.44) | 1.01 (0.71-1.44) | |
c2/c2 | 16 | 13 | 1.61 (1.09-2.36) | 1.64 (1.12-2.41) |
CYP2E1 genotype | Controls n | Colorectal cancer | Colon cancer | Rectal cancer | ||||
n | OR1 (95% CI) | n | OR1 (95% CI) | n | OR1 (95% CI) | |||
Smoker | ||||||||
No | c1/c1 + c1/c2 | 275 | 162 | 1.00 | 57 | 1.00 | 105 | 1.00 |
No | c2/c2 | 5 | 14 | 2.20 (1.31-3.70) | 4 | 1.95 (0.99-3.86) | 10 | 2.30 (1.32-3.99) |
Yes | c1/c1 + c1/c2 | 145 | 129 | 1.34 (0.93-1.92) | 41 | 1.11 (0.66-1.88) | 88 | 1.48 (0.98-2.25) |
Yes | c2/c2 | 8 | 8 | 1.41 (0.50-3.96) | 2 | 0.91 (0.18-4.57) | 6 | 1.75 (0.57-5.42) |
Drinker | ||||||||
No | c1/c1 + c1/c2 | 313 | 174 | 1.00 | 62 | 1.00 | 112 | 1.00 |
No | c2/c2 | 9 | 10 | 1.41 (0.89-2.24) | 2 | 1.09 (0.50-2.38) | 8 | 1.55 (0.95-2.53) |
Yes | c1/c1 + c1/c2 | 107 | 117 | 1.86 (1.28-2.68) | 36 | 1.50 (0.89-2.55) | 81 | 2.07 (1.37-3.14) |
Yes | c2/c2 | 4 | 12 | 5.42 (1.65-17.40) | 4 | 4.74 (1.10-20.40) | 8 | 5.75 (1.65-20.05) |
-
Citation: Gao CM, Takezaki T, Wu JZ, Chen MB, Liu YT, Ding JH, Sugimura H, Cao J, Hamajima N, Tajima K.
CYP2E1 Rsa I polymorphism impacts on risk of colorectal cancer association with smoking and alcohol drinking. World J Gastroenterol 2007; 13(43): 5725-5730 - URL: https://www.wjgnet.com/1007-9327/full/v13/i43/5725.htm
- DOI: https://dx.doi.org/10.3748/wjg.v13.i43.5725