Induction of apoptosis by artemisinin relieving the severity of inflammation in caerulein-induced acute pancreatitis

Table 1 Detection of cell death pathway and pathologic changes in different groups (mean ± SD, n = 8)

	Pathological score	Amylase (U/dL)	Apoptosis index (%)	Oncosis index (%)	Caspase-3 activity
Control	0.25 ± 0.03	2887 ± 298	1.5 ± 0.3	2.1 ± 0.3	0.35 ± 0.04
AP	4.0 ± 0.5a	7821 ± 653a	6.3 ± 0.7a	1.03 ± 0.08a	17.5 ± 2.2a
Artemisinin	3.0 ± 0.5c	5642 ± 721c	11.7 ± 1.4c	13.0 ± 2.4c	1.52 ± 0.21c

AP: Acute pancreatitis.

^aP < 0.05 vs control group;

^cP < 0.05 vs AP group.

Table 2 Inflammatory response of pancreatic tissue in different groups (mean ± SD, n = 8)

	NF-κB activation (%)	MIP-1α protein	MPO (U/g)	IL-1β mRNA
Control	4.7 ± 0.6	0.9 ± 0.1	0.19 ± 0.03	0.5 ± 0.1
AP	42 ± 5.8a	5.8 ± 0.7a	0.68 ± 0.09a	2.4 ± 0.4a
Artemisinin	29 ± 4.1c	3.7 ± 0.5c	0.52 ± 0.06c	1.7 ± 0.3c

MIP: macrophage inflammatory protein; MPO: myeloperoxidase.

^aP < 0.05 vs control group;

^cP < 0.05 vs AP group.