Effects of large dose of dexamethasone on inflammatory mediators and pancreatic cell apoptosis of rats with severe acute pancreatitis

Table 1 Comparison of ascite volumes [M (Q_R)]

Group	3 h	6 h	12 h
Sham operation group	0.50 (0.00)	0.70 (0.50)	0.60 (0.30)
Model group	7.20 (2.00)	6.40 (2.30)	7.90 (1.70)
Dexamethasone treated group	4.50 (2.00)b	4.20 (1.60)b	3.40 (2.70)b

^bP < 0.001, dexamethasone treated group vs model group.

Table 2 Comparison of ascites/body weight ratio [M (Q_R)]

Group	3 h	6 h	12 h
Sham operation group	0.20 (0.04)	0.30 (0 .30)	0.22 (0.10)
Model group	2.38 (1.10)	2.58 (0.70)	2.54 (0.71)
Dexamethasone treated group	1.53 (0.79)b	1.40 (0.63)d	1.36 (0.74)d

^bP < 0.01,

^dP < 0.001, dexamethasone treated group vs model group.

Table 3 Comparison of different indexes level in blood [M (Q_R)]

Index	Sham operation group			Model group			Dexamethasone treated group
	3 h	6 h	12 h	3 h	6 h	12 h	3 h	6 h	12 h
Amylase	2038	2117	1725	7423	8149	9195	6739	7839	7791b
(U/L)	(346)	(324)	(434)	(2275)	(1540)	(1298)	(2310)	(2258)	(1863)
Endotoxin	0.015	0.015	0.016	0.035	0.055	0.056	0.03	0.040b	0.042b
(EU/mL)	(0.007)	(0.007)	(0.005)	(0.017)	(0.025)	(0.0195)	(0.014)	(0.012)	(0.018)
TNF-α	3.3	4.9	3.7	46.125	77.535	67.301	38.4	58.3a	38.7a
(ng/L)	(3.6)	(2.6)	(2.3)	(37.954)	(42.157)	(32.1315)	(26.6)	(26.4)	(28.5)
IL-6	1.75	1.75	1.48	4.87	6.65	5.65	3.31b	3.17b	3.36b
(ng/L)	(0.65)	(1.04)	(0.57)	(1.38)	(1.45)	(1.08)	(1.38)	(1.28)	(1.56)

^aP < 0.05,

^bP < 0.01, dexamethasone treated group vs model group.

Table 4 Comparison of serum PLA₂ content (mean ± SD, U/mL)

Group	3 h	6 h	12 h
Sham operation group	18.70 ± 4.40	16.70 ± 3.83	18.52 ± 11.32
Model group	103.70 ± 20.82	119.85 ± 17.74	121.29 ± 17.00
Dexamethasone treated group	53.96 ± 15.4b	67.75 ± 27.95b	65.27 ± 26.21b

^bP < 0.001, dexamethasone treated group vs model group.

Table 5 Comparison of pathological score of pancreas [M (Q_R)]

Group	3 h	6 h	12 h
Sham operation group	0.00 (1.00)	0.00 (1.00)	0.00 (1.00)
Model group	8.00 (2.00)	9.00 (2.00)	11.00 (1.50)
Dexamethasone treated group	7.00 (2.00)a	8.00 (2.00)a	8.00 (1.00)b

^aP < 0.05,

^bP < 0.01, dexamethasone treated group vs model group.

Table 6 Comparison of apoptosis index of the head and tail of pancreas [M (Q_R)]

Group (t/h)	Pancreas head			Pancreas tail
	3 h	6 h	12 h	3 h	6 h	12 h
Sham operation group	0.00 (0.00)	0.00 (0.00)	0.00 (0.00)	0.00 (0.00)	0.00 (0.00)	0.00 (0.00)
Model group	0.00 (0.00)	0.00 (0.00)	0.00 (0.00)	0.00 (0.00)	0.00 (0.00)	0.00 (0.00)
Dexamethasone treated group	0.00 (0.00)	0.00 (2.00)b	0.00 (0.00)	0.00 (0.00)	0.20 (1.80)b	0.00 (0.00)

^bP < 0.01, dexamethasone treated group vs model group.