Rapid Communication
Copyright ©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Oct 14, 2007; 13(38): 5127-5132
Published online Oct 14, 2007. doi: 10.3748/wjg.v13.i38.5127
Table 1 Body mass and serum biochemical parameters in all groups
Parameter(mean ± SEM)Control(n = 8)NASH(n = 8)NASH + NAC20(n = 9)
Body mass (g) at the beginning239.0 ± 2.27245.1 ± 1.0251.4 ± 1.7
at 6 wk438.4 ± 9.7197.0 ± 8.1a207.8 ± 6.9a
AST (U/L)86.8 ± 4.353.6 ± 9.3a65.6 ± 8.7
ALT (U/L)40.2 ± 2.423.0 ± 1.9a25.4 ± 5.7a
Cholesterol (g/L)71.8 ± 1.894.8 ± 3.1a91.4 ± 3.5a
Triglycerides (g/L)90.3 ± 19.1147.8 ± 32.689.2 ± 28.2
Table 2 Effects of NAC on liver histology in rats with NASH (scores)
GroupnSteatosis
Necroinflammation
01230123
Control88---8---
NASH8--53-521
NASH + NAC209-6213411