Basic Research
Copyright ©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Oct 14, 2007; 13(38): 5079-5089
Published online Oct 14, 2007. doi: 10.3748/wjg.v13.i38.5079
Table 1 Comparison of different indexes level in blood [M (QR)]
Sham operation groupModel groupBaicalin treated groupOctreotide treated group
Endotoxin (EU/mL)3 h0.016 (0.005)0.053 (0.029)0.027 (0.005)0.033 (0.006)
6 h0.016 (0.010)0.059 (0.037)0.039 (0.019)0.031 (0.010)
12 h0.014 (0.015)0.060 (0.022)0.034 (0.015)0.042 (0.014)
BUN (mmol/L)3 h5.310 (0.940)12.050 (4.030)10.530 (3.625)9.850 (3.020)
6 h5.500 (2.200)17.390 (3.850)12.220 (4.530)13.930 (5.500)
12 h4.860 (1.590)22.270 (11.375)13.720 (4.380)13.520 (9.810)
NO (μmol/L)3 h7.500 (5.000)65.000 (7.50)57.500 (22.50)52.500 (15.00)
6 h7.500 (5.000)62.500 (38.75)47.500 (37.50)57.500 (15.00)
12 h74.100 (26.15)57.500 (27.50)45.000 (12.50)
TNF-α (pg/mL)3 h3.900 (3.200)41.440 (37.72)44.930 (45.84)39.300 (30.60)
6 h4.000 (1.700)92.150 (23.12)65.100 (27.51)47.600 (16.50)
12 h5.3000 (3.000)65.020 (26.81)47.650 (25.52)54.500 (41.40)
IL-6 (pg/mL)3 h1.846 (0.346)5.437 (1.025)3.031 (0.870)2.646 (1.373)
6 h1.743 (0.838)6.817 (0.810)2.882 (1.392)3.076 (1.205)
12 h2.036 (0.818)5.356 (0.747)2.832 (0.597)2.462 (1.353)
ET-1 (pg/mL)3 h15.293 (4.231)24.745 (1.011)19.635 (6.065)16.827 (3.775)
6 h16.275 (3.180)25.625 (7.973)16.226 (3.174)14.855 (5.747)
12 h14.173 (2.556)24.725 (3.759)18.625 (5.780)15.185 (1.761)
Table 2 Comparison of serum CREA content (mean ± SD, μmol/L)
Groups3 h   6 h12 h
Sham operation group17.867 ± 2.89021.467 ± 3.04419.733 ± 3.150
Model group38.400 ± 11.34445.154 ± 17.43541.500 ± 12.122
Baicalin-treated group37.615 ± 9.48339.867 ± 13.64850.733 ± 29.310
Octreotide-treated group29.200 ± 5.71033.533 ± 10.10633.933 ± 9.145
Table 3 Pathological score standard of kidney
GradeObservation indexes
INo cellular proliferation or fibrosis in renal glomerulus; no capillary congestion or microthrombus; swelling and blurry boundary of renal tubular epithelial cell; stegnosis or atresia of lumens; protein cast and renal interstitial edema
IIGlomerular capillary congestion, scattered necrosis in renal tubular epithelial cell, interstitial edema and inflammatory cell infiltration
IIIII + lamellar necrosis of renal tubular epithelial cell
Table 4 Comparision of pathological score of kidney in all groups [M (QR)]
Groups3 h6 h12 h
Sham operation group0.00 (0.00)0.00 (0.00)0.00 (0.00)
Model group2.00 (1.00)2.00 (1.00)2.00 (1.25)
Baicalin treated group1.00 (1.00)1.00 (1.00)2.00 (1.00)
Octreotide-treated group1.00 (1.00)1.00 (1.00)1.00 (1.00)
Table 5 Expression of Bax protein in kidney
GroupsnPathologic grade
-++++++
Sham operation group(3 h)1515
(6 h)1515
(12 h)1515
Model group(3 h)15744
(6 h)131012
(12 h)107111
Baicalin treated group(3 h)151131
(6 h)151041
(12 h)15123
Octreotide treated group(3 h)15123
(6 h)151122
(12 h)151041
Table 6 Comparision of Bax protein in kidney [M (QR)] grade score
Groups3 h6 h12 h
Sham operation group0.00 (0.00)0.00 (0.00)0.00 (0.00)
Model group1.00 (2.00)0.00 (0.50)0.00 (1.25)
Baicalin-treated group0.00 (0.50)0.00 (1.00)0.00 (0.00)
Octreotide-treated group0.00 (0.00)0.00 (1.00)0.00 (1.00)
Table 7 Expression of Bcl-2 protein in kidney
GroupsnPathologic grade
-++++++
Sham operation group(3 h)1515
(6 h)1515
(12 h)1515
Model group(3 h)1510122
(6 h)13418
(12 h)10712
Baicalin-treated group(3 h)15141
(6 h)1515
(12 h)15114
Octreotide-treated group(3 h)15132
(6 h)1515
(12 h)1515
Table 8 Comparison of Bcl-2 protein in kidney [M (QR)] grade score
Groups3 h6 h12 h
Sham operation group0.00 (0.00)0.00 (0.00)0.00 (0.00)
Model group0.00 (2.00)3.00 (3.00)0.00 (1.25)
Baicalin-treated group0.00 (0.00)0.00 (0.00)0.00 (1.00)
Octreotide-treated group0.00 (0.00)0.00 (0.00)0.00 (0.00)
Table 9 Apoptotic index of kidney [M (QR)] (%)
Groups3 h6 h12 h
Sham operation group0.00 (0.00)0.00 (0.00)0.00 (0.00)
Model group0.00 (0.00)0.00 (0.00)0.00 (0.00)
Baicalin-treated group0.00 (0.01)0.00 (0.02)0.00 (0.00)
Octreotide-treated group0.00 (0.00)0.00 (0.04)0.00 (0.00)
Table 10 Comparison of serum PLA2 content (mean ± SD, U/mL)
Groups3 h6 h12 h
Sham operation group14.62 ± 3.0217.49 ± 3.8219.02 ± 5.07
Model group76.10 ± 16.70101.46 ± 14.67105.33 ± 18.10
Baicalin-treated group56.25 ± 22.4367.91 ± 20.6166.86 ± 22.10
Octreotide-treated group74.37 ± 19.9463.13 ± 26.3153.63 ± 12.28