Zhang XP, Tian H, Lai YH, Chen L, Zhang L, Cheng QH, Yan W, Li Y, Li QY, He Q, Wang F. Protective effects and mechanisms of Baicalin and octreotide on renal injury of rats with severe acute pancreatitis. World J Gastroenterol 2007; 13(38): 5079-5089 [PMID: 17876873 DOI: 10.3748/wjg.v13.i38.5079]
Corresponding Author of This Article
Xi-Ping Zhang, MD, Department of General Surgery, Hangzhou First People’s Hospital, 261 Huansha Road, Hangzhou 310006, Zhejiang Province, China. zxp99688@vip.163.com
Article-Type of This Article
Basic Research
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
No cellular proliferation or fibrosis in renal glomerulus; no capillary congestion or microthrombus; swelling and blurry boundary of renal tubular epithelial cell; stegnosis or atresia of lumens; protein cast and renal interstitial edema
II
Glomerular capillary congestion, scattered necrosis in renal tubular epithelial cell, interstitial edema and inflammatory cell infiltration
III
II + lamellar necrosis of renal tubular epithelial cell
Table 4 Comparision of pathological score of kidney in all groups [M (QR)]
Groups
3 h
6 h
12 h
Sham operation group
0.00 (0.00)
0.00 (0.00)
0.00 (0.00)
Model group
2.00 (1.00)
2.00 (1.00)
2.00 (1.25)
Baicalin treated group
1.00 (1.00)
1.00 (1.00)
2.00 (1.00)
Octreotide-treated group
1.00 (1.00)
1.00 (1.00)
1.00 (1.00)
Table 5 Expression of Bax protein in kidney
Groups
n
Pathologic grade
-
+
++
+++
Sham operation group
(3 h)
15
15
(6 h)
15
15
(12 h)
15
15
Model group
(3 h)
15
7
4
4
(6 h)
13
10
1
2
(12 h)
10
7
1
1
1
Baicalin treated group
(3 h)
15
11
3
1
(6 h)
15
10
4
1
(12 h)
15
12
3
Octreotide treated group
(3 h)
15
12
3
(6 h)
15
11
2
2
(12 h)
15
10
4
1
Table 6 Comparision of Bax protein in kidney [M (QR)] grade score
Groups
3 h
6 h
12 h
Sham operation group
0.00 (0.00)
0.00 (0.00)
0.00 (0.00)
Model group
1.00 (2.00)
0.00 (0.50)
0.00 (1.25)
Baicalin-treated group
0.00 (0.50)
0.00 (1.00)
0.00 (0.00)
Octreotide-treated group
0.00 (0.00)
0.00 (1.00)
0.00 (1.00)
Table 7 Expression of Bcl-2 protein in kidney
Groups
n
Pathologic grade
-
+
++
+++
Sham operation group
(3 h)
15
15
(6 h)
15
15
(12 h)
15
15
Model group
(3 h)
15
10
1
2
2
(6 h)
13
4
1
8
(12 h)
10
7
1
2
Baicalin-treated group
(3 h)
15
14
1
(6 h)
15
15
(12 h)
15
11
4
Octreotide-treated group
(3 h)
15
13
2
(6 h)
15
15
(12 h)
15
15
Table 8 Comparison of Bcl-2 protein in kidney [M (QR)] grade score
Citation: Zhang XP, Tian H, Lai YH, Chen L, Zhang L, Cheng QH, Yan W, Li Y, Li QY, He Q, Wang F. Protective effects and mechanisms of Baicalin and octreotide on renal injury of rats with severe acute pancreatitis. World J Gastroenterol 2007; 13(38): 5079-5089