Viral Hepatitis
Copyright ©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Sep 14, 2007; 13(34): 4560-4565
Published online Sep 14, 2007. doi: 10.3748/wjg.v13.i34.4560
Table 1 Characteristics of patients with genotypes B and C
< 30-yr-old group
≥ 30-yr-old group
Genotype BGenotype CGenotype BGenotype C
Number of patients27234130
Age (yr, mean ± SD)21.6 ± 5.322.2 ± 4.445.5 ± 10.842.7 ± 8.7
Gender (Male/Female)19/816/737/422/8
HBeAg (+/-)24/321/24/3719/11b
Observation period69.0 ± 53.462.8 ± 45.977.9 ± 50.187.0 ± 50.6
(mo, mean ± SD)
ALT (IU/L, mean ± SD)266.3 ± 262.1245.8 ± 292.4223.1 ± 251.7265.8 ± 359.8
Degree of fibrosis (0/1/2/3)4/11/5/12/13/2/26/13/10/42/13/6/7
Table 2 Cox proportional hazard analysis for development of LC
< 30-yr-old group
≥ 30-yr-old group
VariablesRelativerisk95% CIPRelativerisk95% CIP
Gender (Male/Female)0-0.97200.000-3.9930.969
HBeAg
Positive10.028-6.4690.53810.185-3.2500.727
Negative2.361.29
Degree of fibrosis
Mild-moderate10.080-1.0300.05310.296-3.2380.972
Severe10.871.02
Genotypes
B10.019-2.8330.25810.033-0.9160.039
C4.245.75
Table 3 Patients progressing to liver cirrhosis during the observation period
Genotype B Age (yr)Genotype C Age (yr)
At entry
Developmentof LC
Outcome
At entry
Developmentof LC
Outcome
17 M e+18 e+24 e-18 M e+24 e+31 e+ dead (HCC)
23 M e+27 e-36 e-
28 M e+30 e+38 e-
31 M e+33 e+40 e+ dead (hepatic failure)
31 M e+39 e+44 e-
33 M e+40 e+48 e+
36 M e+40 e-46 e-
38 M e+45 e-48 e- dead (HCC)
41 M e-48 e-49 e-41 M e+43 e+51 e-
42 M e+46 e-48 e-
45 M e-48 e-49 e- dead (HCC)
58 M e-64 e-70 e-50 M e-54 e-57 e-
58 M e-72 e-73 e-50 M e-52 e-53 e- dead (hepatic failure)
60 M e-61 e-66 e-
66 M e-70 e-71 e-73 F e+79 e+90 e+