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©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Sep 14, 2007; 13(34): 4560-4565
Published online Sep 14, 2007. doi: 10.3748/wjg.v13.i34.4560
Published online Sep 14, 2007. doi: 10.3748/wjg.v13.i34.4560
Table 1 Characteristics of patients with genotypes B and C
< 30-yr-old group | ≥ 30-yr-old group | |||
Genotype B | Genotype C | Genotype B | Genotype C | |
Number of patients | 27 | 23 | 41 | 30 |
Age (yr, mean ± SD) | 21.6 ± 5.3 | 22.2 ± 4.4 | 45.5 ± 10.8 | 42.7 ± 8.7 |
Gender (Male/Female) | 19/8 | 16/7 | 37/4 | 22/8 |
HBeAg (+/-) | 24/3 | 21/2 | 4/37 | 19/11b |
Observation period | 69.0 ± 53.4 | 62.8 ± 45.9 | 77.9 ± 50.1 | 87.0 ± 50.6 |
(mo, mean ± SD) | ||||
ALT (IU/L, mean ± SD) | 266.3 ± 262.1 | 245.8 ± 292.4 | 223.1 ± 251.7 | 265.8 ± 359.8 |
Degree of fibrosis (0/1/2/3) | 4/11/5/1 | 2/13/2/2 | 6/13/10/4 | 2/13/6/7 |
Table 2 Cox proportional hazard analysis for development of LC
< 30-yr-old group | ≥ 30-yr-old group | |||||
Variables | Relativerisk | 95% CI | P | Relativerisk | 95% CI | P |
Gender (Male/Female) | 0 | - | 0.972 | 0 | 0.000-3.993 | 0.969 |
HBeAg | ||||||
Positive | 1 | 0.028-6.469 | 0.538 | 1 | 0.185-3.250 | 0.727 |
Negative | 2.36 | 1.29 | ||||
Degree of fibrosis | ||||||
Mild-moderate | 1 | 0.080-1.030 | 0.053 | 1 | 0.296-3.238 | 0.972 |
Severe | 10.87 | 1.02 | ||||
Genotypes | ||||||
B | 1 | 0.019-2.833 | 0.258 | 1 | 0.033-0.916 | 0.039 |
C | 4.24 | 5.75 |
Table 3 Patients progressing to liver cirrhosis during the observation period
Genotype B Age (yr) | Genotype C Age (yr) | ||||
At entry | Developmentof LC | Outcome | At entry | Developmentof LC | Outcome |
17 M e+ | 18 e+ | 24 e- | 18 M e+ | 24 e+ | 31 e+ dead (HCC) |
23 M e+ | 27 e- | 36 e- | |||
28 M e+ | 30 e+ | 38 e- | |||
31 M e+ | 33 e+ | 40 e+ dead (hepatic failure) | |||
31 M e+ | 39 e+ | 44 e- | |||
33 M e+ | 40 e+ | 48 e+ | |||
36 M e+ | 40 e- | 46 e- | |||
38 M e+ | 45 e- | 48 e- dead (HCC) | |||
41 M e- | 48 e- | 49 e- | 41 M e+ | 43 e+ | 51 e- |
42 M e+ | 46 e- | 48 e- | |||
45 M e- | 48 e- | 49 e- dead (HCC) | |||
58 M e- | 64 e- | 70 e- | 50 M e- | 54 e- | 57 e- |
58 M e- | 72 e- | 73 e- | 50 M e- | 52 e- | 53 e- dead (hepatic failure) |
60 M e- | 61 e- | 66 e- | |||
66 M e- | 70 e- | 71 e- | 73 F e+ | 79 e+ | 90 e+ |
- Citation: Maeshiro T, Arakaki S, Watanabe T, Aoyama H, Shiroma J, Yamashiro T, Hirata T, Hokama A, Kinjo F, Nakayoshi T, Nakayoshi T, Mizokami M, Fujita J, Sakugawa H. Different natural courses of chronic hepatitis B with genotypes B and C after the fourth decade of life. World J Gastroenterol 2007; 13(34): 4560-4565
- URL: https://www.wjgnet.com/1007-9327/full/v13/i34/4560.htm
- DOI: https://dx.doi.org/10.3748/wjg.v13.i34.4560