Expression of Angiopoietin-1, 2 and 4 and Tie-1 and 2 in gastrointestinal stromal tumor, leiomyoma and schwannoma

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Sep 7, 2007 (publication date) through Nov 28, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical Research

World J Gastroenterol. Sep 7, 2007; 13(33): 4473-4479
Published online Sep 7, 2007. doi: 10.3748/wjg.v13.i33.4473

Table 1 Tie and Ang immunohistochemistry in intestinal stromal tumors n (%)

^aP < 0.001 vs leiomyoma.

Table 2 Tie and Ang expression and risk categories for GISTs (30 cases) n (%)

		Ang-1		Ang-2		Ang-4		Tie-1		Tie-2
	n	-	+	-	+	-	+	-	+	-	+
GIST	30	10 (33.3)	20 (66.7)	5 (16.7)	25 (83.3)	19 (63.3)	11 (36.7)	12 (40.0)	18 (60.0)	27 (90.0)	3 (10.0)
Risk categories		NS		NS		NS		NS		NS
High	6	1 (16.7)	5 (83.3)	2 (33.3)	4 (66.7)	6 (100)	0 (0.0)	1 (16.7)	5 (83.3)	5 (83.3)	1 (16.7)
Intermediate	4	2 (50.0)	2 (50.0)	1 (25.0)	3 (75.0)	2 (50.0)	2 (50.0)	2 (50.0)	2 (50.0)	4 (100)	0 (0.0)
Low	15	6 (40.0)	9 (60.0)	2 (13.3)	13 (86.7)	8 (53.3)	7 (46.7)	5 (33.3)	10 (66.7)	13 (86.7)	2 (13.3)
Very low	5	1 (20.0)	4 (80.0)	0 (0.0)	5 (100)	3 (60.0)	2 (40.0)	4 (80.0)	1 (20.0)	5 (100)	0 (0.0)
Mitosis counts (per 50 fields, HPF)		NS		NS		NS		NS		NS
< 2	19	7 (36.8)	12 (63.2)	3 (15.8)	16 (84.2)	11 (57.9)	8 (42.1)	9 (47.4)	10 (52.6)	17 (89.5)	2 (10.5)
2-5	7	2 (28.6)	5 (71.4)	1 (14.3)	6 (85.7)	4 (57.1)	3 (42.9)	2 (28.6)	5 (71.4)	6 (85.7)	1 (14.3)
6-10	2	1 (50.0)	1 (50.0)	1 (50.0)	1 (50.0)	2 (100)	0 (0.0)	0 (0.0)	2 (100)	2 (100)	0 (0.0)
10 <	2	0 (0.0)	2 (100)	0 (0.0)	2 (100)	2 (100)	0 (0.0)	1 (50.0)	1 (50.0)	2 (100)	0 (0.0)
Tumor size (cm in length)		NS		NS		NS		NS		NS
< 2	4	1 (25.0)	3 (75.0)	0 (0.0)	4 (100)	3 (75.0)	1 (25.0)	3 (75.0)	1 (25.0)	4 (100)	0 (0.0)
2-5	16	6 (37.5)	10 (62.5)	2 (12.5)	14 (87.5)	9 (56.3)	7 (43.8)	6 (37.5)	10 (62.5)	15 (93.8)	1 (6.3)
5-10	7	3 (42.9)	4 (57.1)	2 (28.6)	5 (71.4)	4 (57.1)	3 (42.9)	2 (28.6)	5 (71.4)	6 (85.7)	1 (14.3)
> 10	3	0 (0.0)	3 (100)	1 (33.3)	2 (66.7)	3 (100)	0 (0.0)	1 (33.3)	2 (66.7)	2 (66.7)	1 (33.3)

NS: not significant.

Citation: Nakayama T, Inaba M, Naito S, Mihara Y, Miura S, Taba M, Yoshizaki A, Wen CY, Sekine I. Expression of Angiopoietin-1, 2 and 4 and Tie-1 and 2 in gastrointestinal stromal tumor, leiomyoma and schwannoma. World J Gastroenterol 2007; 13(33): 4473-4479
URL: https://www.wjgnet.com/1007-9327/full/v13/i33/4473.htm
DOI: https://dx.doi.org/10.3748/wjg.v13.i33.4473