Safety evaluation of donors for living-donor liver transplantation in Chinese mainland: A single-center report

Table 1 Evaluated donor demographics (n = 115)

Evaluated donors	Evaluated and accepteddonors		Evaluated and rejecteddonors
Age (yr, range, mean ± SD)	27-58 (36.4 ± 12.3)		31-55 (37.4 ± 10.6)
Weight (kg, mean ± SD)	53.7 ± 12.9		64.4 ± 14.3
Sex	M	13	23
	F	37	42
Relationship to recipient	Mother	33	16
	Father	12	28
	Wife	2	9
	Husband	0	3
	Uncle	1	5
	Sister/brother	1	4
	Volunteer	1	0

Table 2 Current donor evaluation protocol at the First Affiliated Hospital of Nanjing Medical University

Basic requirements	20–60 yr
	Relationship: relatives or unrelated volunteers
	Blood type: identical or compatible
Step I	Clinical evaluation: initial informed consent, history and physical examination
	Laboratory: blood group, liver and renal function
	Serology: HBsAg, HBsAb, HBcAb, anti-HCV, anti-HIV
Step II	Clinical examination: psychological evaluation
	Laboratory: hematology, coagulation profile, blood sugar, electrolytes, HLA typing, cross-matching, alpha-1- antitrypsin, ferritin, tumor markers (AFP, CEA,CA199, CA50), arterial blood gas,urine and stool analysis, pregnancy test (female)
	Serology: HBV DNA, RPR, antibody for CMV, EBV, HSV, varicella and rubella viruses
	Imaging study: Chest radiograph, abdominal ultrasound, ECG
Step III	Imaging study: CT angiography and volumetry, MR cholangiography

Table 3 Exclusion criteria for 65 potential donors

Step	Exclusion	n
I	Clinical evaluation	4
	Blood type	27
	Diabetes	1
	Hepatitis B (core Ab +)	17
	Hepatitis C	2
	Autoimmune hepatitis	1
II	Psychological evaluation	1
	Cardiac evaluation	2
III	CT or MRI findings	1
	CT volumetry (steatosis-GRBW)	3
IV	Second consent	6

GRBW: graft recipient body weight.

Table 4 Donor medical outcomes

Donor medical outcomes	n (%)
Survival	50/50 (100)
Complications
Major	6/50 (12.0)
Biliary leak	2
Pneumonia	2
Initial stage of liver dysfunction	1
Pleural effusions	1
Minor	14/50 (28.0)
Delay in return to normal bowel function	5
Pain	3
Sore throat	2
Foot paresthesias	2
Persistent short-term memory loss	1
Chronic fatigue	1
Ongoing symptoms
Yes	28 (56.0)
No	22 (44.0)
Abdominal discomfort	15
Scar numbness	6
Loss of appetite, nausea	3
Poor appetite	3
Diarrhea	2
Weakness	1
Nausea	1
Difficulty sleeping	1
Sought other physician assistance
Yes	12 (42.9)
No	16 (51.1)

Major and minor complications are defined in Methods. Under ongoing symptoms, the number of symptoms reported is greater than 28.