Change in expression of apoptosis genes after hyperthermia, chemotherapy and radiotherapy in human colon cancer transplanted into nude mice

Table 1 Average optical density of p53, Bcl-2 and Bax in different groups 48 h after treatment (mean ± SD)

Group	n	p53	Bcl-2	Bax
A	6	0.208 ± 0.009	0.086 ± 0.010	0.091 ± 0.0013
B	6	0.223 ± 0.0133	0.056 ± 0.0064	0.135 ± 0.0095
C	6	0.255 ± 0.0111	0.064 ± 0.0048	0.128 ± 0.0144
D	6	0.197 ± 0.0157	0.058 ± 0.0095	0.151 ± 0.011
E	6	0.205 ± 0.100	0.054 ± 0.0090	0.150 ± 0.028
F	6	0.155 ± 0.0115	0.026 ± 0.0170	0.207 ± 0.027
F		40.810b	21.466b	23.912b

Group A: hyperthermia; group B: chemotherapy; group C: themo-chermotherapy; group D: radiation; group E: themoradiotherapy; group F: thempchempradiotherapy.

^bP < 0.01 in groups A-F. Comparison of average optical density of Bcl-2, Bax and p53 genes in different groups was made by mono-factor variance analysis. SNQ test was used to compare the two groups.