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©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Aug 28, 2007; 13(32): 4345-4349
Published online Aug 28, 2007. doi: 10.3748/wjg.v13.i32.4345
Published online Aug 28, 2007. doi: 10.3748/wjg.v13.i32.4345
Table 1 Clinical and demographic data of patients with HCC at the time of the diagnosis
| Clinical features | mean ± SD or percentage (%) |
| Age (yr) | 55.0 ± 13.6 (range, 26-89) |
| Sex (male:female) | 60:10 |
| Etiology | |
| Alcohol dependence | 9/70 (12.8) |
| HBsAg-positive | 39/70 (55.7) |
| Anti-HCV-positive | 7/70 (10) |
| HBsAg- and anti-HCV-positive | 2/70 (2.9) |
| Unknown | 13/70 (18.6) |
| Liver function test | |
| Total bilirubin (mg%) | 2.3 ± 3.5 |
| Albumin (g/dL) | 3.5 ± 0.7 |
| AST (IU/L) | 150.9 ± 130.4 |
| ALT (IU/L) | 82.9 ± 84.1 |
| Alkaline phosphatase (IU/L) | 512.0 ± 317.9 |
| Prothrombin time (s) | 14.4 ± 4.2 |
| Child-Pugh classification | |
| A | 43/70 (61.4) |
| B | 23/70 (32.9) |
| C | 4/70 (5.7) |
| Okuda staging system | |
| 1 | 19/70 (27.2) |
| 2 | 46/70 (65.7) |
| 3 | 5/70 (7.1) |
| Venous invasion | 17/70 (24.3) |
| Extrahepatic metastasis | 12/70 (17.1) |
| AFP (≥ 400 ng/mL) | 27/70 (38.6) |
Table 2 Serum levels of interleukins in patients with HCC and in healthy controls
| Healthy controls | HCC patients | P | |
| (n = 10) | (n = 70) | ||
| IL-6 (pg/mL) | 2.9 ± 13.4 | 31.2 ± 52.2 | 0.01 |
| IL-12 (pg/mL) | 1.5 ± 0.9 | 6.2 ± 9.6 | 0.03 |
| IL-18 (pg/mL) | 38.5 ± 22.4 | 104.6 ± 65.8 | 0.002 |
Table 3 Comparison of clinical data of patients with HCC according to serum IL-18 levels
| Clinical features | IL-18 < 105 pg/mL | IL-18 ≥ 105 pg/mL | P |
| (n = 41) | (n = 29) | ||
| Age (yr ) | 54.9 ± 15.3 | 55.2 ± 11.1 | NS |
| Sex (male:female) | 34:7 | 26:3 | NS |
| Liver function test | |||
| Total bilirubin (mg%) | 1.4 ± 0.7 | 3.6 ± 4.9 | 0.03 |
| Albumin (g/dL) | 3.8 ± 0.7 | 3.3 ± 0.7 | 0.01 |
| AST (IU/L) | 136.8 ± 116.4 | 170.8 ± 148.3 | NS |
| ALT (IU/L) | 66.5 ± 39.2 | 106.2 ± 119.7 | NS |
| Alkaline phosphatase (IU/L) | 436.9 ± 275.2 | 612.1 ± 348.2 | 0.04 |
| Prothrombin time (s) | 13.9 ± 2.4 | 14.9 ± 5.8 | NS |
| Okuda staging (1:2:3) | 15:25:1 | 4:21:4 | 0.03 |
| Venous invasion (+:-) | 6:35 | 11:18 | 0.02 |
| Extrahepatic metastasis (+:-) | 6:35 | 6:29 | NS |
| AFP (< 400 ng/mL: ≥ 400 ng/mL) | 25:16 | 18:11 | NS |
Table 4 Multivariate analysis of prognostic factors of survival with Cox’s proportional hazards model
| Factors | Risk ratio (95% CI) | P |
| High serum IL-18 level | 1.86 (1.11-3.11) | 0.019 |
| Presence of venous invasion | 2.09 (1.19-3.67) | 0.010 |
| No receiving therapy | 5.01 (2.49-10.06) | < 0.001 |
- Citation: Tangkijvanich P, Thong-ngam D, Mahachai V, Theamboonlers A, Poovorawan Y. Role of serum interleukin-18 as a prognostic factor in patients with hepatocellular carcinoma. World J Gastroenterol 2007; 13(32): 4345-4349
- URL: https://www.wjgnet.com/1007-9327/full/v13/i32/4345.htm
- DOI: https://dx.doi.org/10.3748/wjg.v13.i32.4345