Noninvasive diagnosis of hepatic fibrosis in chronic hepatitis C

Table 1 Overview of studies on noninvasive fibrosis tests in chronic hepatitis C

	n	Significantfibrosis	Cirrhosis	Author
		(AUROC)	(AUROC)
Indirect fibrosis tests
AST/ALT ratio	194	0.57	0.73	Lackner[21]
	409	0.75	-	Giannini[20]
Platelet count	194	0.71	0.89	Lackner[21]
	409	0.73	-	Giannini[20]
APRI	270	0.80 (0.881)	0.89 (0.941)	Wai[25]
	194	0.8	0.9	Lackner[21]
	503	0.79	-	Cales[26]
	235	0.71	0.81	Bourliere[27]
	206	0.82	0.84	Parise[28]
	360	0.79 (0.821)	-	Koda[29]
	356	0.76	0.92	Halfon[30]
Model 3	1141	-	0.78 (0.811)	Lok[31]
Forns index	476	0.86 (0.811)	-	Forns[32]
	503	0.82	-	Cales[26]
	235	0.76	-	Bourliere[27]
	360	0.79 (0.841)	-	Koda[29]
Fibrotest/Fibrosure	339	0.84 (0.871)	0.92	Imbert-Bismut[34]
	352	0.73	-	Poynard[36]
	323	0.84	-	Myers[35]
	125	0.74	-	Rossi[37]
	503	0.81	-	Cales[26]
	519	0.79	-	Halfon[38]
	235	0.81	0.82	Bourliere[27]
	356	0.79	0.86	Halfon[30]
FibroIndex	360	0.83 (0.861)	-	Koda[29]
Direct fibrosis tests
Hyaluronic acid	326	0.86	0.92	Guechot[42]
	206	0.88	0.91	Parise[28]
PIIINP	326	0.69	0.73	Guechot[42]
TIMP-1	78	0.71	0.90	Boeker[49]
YKL-40	109	0.81	0.80	Saitou[51]
Composite fibrosis panels
Fibrospect II	696	0.83 (0.821)	-	Patel[52]
	503	0.87	-	Cales[26]
ELF	10212	0.78	0.89	Rosenberg[53]
	503	0.83	-	Cales[26]
Hepascore	221	0.85 (0.821)	0.94 (0.891)	Adams[54]
	356	0.76	0.89	Halfon[30]
Fibrometer	503	0.88	-	Cales[26]
	356	0.78	0.94	Halfon[30]
Elastography
Transient elastography	327	0.79	0.97	Ziol[56]
(Fibroscan)	7112	0.80	0.96	Foucher[59]
	403	1.00	-	Colletta[58]
	7752	-	0.95	Ganne-Carrie[60]
	935	0.79	0.91	Kettaneh[61]
Real-time elastography	79	0.75	0.69	Friedrich-Rust[64]
Combined tests
Fibroscan + Fibrotest	183	0.88	0.95	Castera[66]

¹Internal validation set;

²Chronic liver disease of various etiologies;

³Chronic HCV with persistently normal ALT.