Effect of Qi-protecting powder (Huqi San) on expression of c-jun, c-fos and c-myc in diethylnitrosamine-mediated hepatocarcinogenesis

Table 1 Effect of Huqi San on the number and size of DEN-induced γ-GT positive foci in rat liver (mean ± SD)

Experimental groups	n	Number of γ-GTfoci (per cm2)	Area of γ-GTfoci (mm2/cm2)
Normal group	10	0.23 ± 0.09a	0.18 ± 0.08a
PH group	12	0.31 ± 0.08a	0.21 ± 0.10a
Prevention group	12	4.96 ± 0.72a	5.12 ± 3.62a
Large dose therapeutic group (8 g/kg body weight)	12	7.53 ± 0.88a	8.76 ± 3.97a
Small dose therapeutic group (4 g/kg body weight)	12	12.77 ± 0.93b	13.63 ± 3.44b
Model group	12	29.46 ± 2.17	21.1 ± 2.98

^aP < 0.001,

^bP < 0.01 vs model group; γ-GT: γ-glutamy-transpeptidase.

Table 2 Effect of Huqi San on c-jun, c-fos and c-myc protein level in liver (mean ± SD, mm²)

	c-jun protein		c-fos protein		c-myc protein
Experimental groups	Level	Fold of control	Level	Fold of control	Level	Fold of control
Normal group	0.28 ± 0.03a	-	0.29 ± 0.04a	-	0.12 ± 0.02a	-
PH group	0.24 ± 0.02a	0.86	0.29 ± 0.03a	1.00	0.17 ± 0.01a	1.41
Prevention group	0.41 ± 0.01a	1.46	0.33 ± 0.09a	1.14	0.36 ± 0.07a	3.00
Large dose herapeutic group (8 g/kg body weight )	0.58 ± 0.02b	2.07	0.56 ± 0.02b	1.93	0.48 ± 0.01a	4.00
Small dose therapeutic group (4 g/kg body weight )	0.71 ± 0.06b	2.54	0.77 ± 0.08a	2.66	0.69 ± 0.06b	5.75
Model group	0.89 ± 0.03	3.18	0.91 ± 0.07	3.14	0.99 ± 0.04	8.25

^aP < 0.001,

^bP < 0.01 vs model group.