Effect of emodin on pancreatic fibrosis in rats

Table 1 Grading of pancreatic fibrosis

Grade	Ductdilation	Periductalfibrosis	Intralobularfibrosis	Glandularatrophy
F0	-	-	-	-
F1	+	-	-	-
F2	+	+	-	-
F3	+	+	+	-
F4	+	+	+	+

Table 2 Effect of emodin on serum hyaluronic acid (HA) and laminin (LN) (mean ± SE)

Group	n	HA (μg/L)	LN (μg/L)
1 (Normal)	10	55.2 ± 23.7	40.5 ± 12.2
2 (Control)	8	112.7 ± 26.5b	86.2 ± 16.5b
3 (emodin, 20 mg/kg)	8	86.6 ± 22.1a	66.8 ± 14.4a
4 (emodin, 40 mg/kg)	8	78.0 ± 24.5d	56.7 ± 12.3a
5 (emodin, 80 mg/kg)	9	62.2 ± 19.3d	44.3 ± 10.4d

^bP < 0.01 vs group 1;

^aP < 0.05,

^dP < 0.01 vs group 2.

Table 3 Pancreatic collagen content in different groups (mean ± SE, %)

Group	n	Positive proportion
2 (Control)	8	42 ± 6
3 (emodin, 20 mg/kg)	8	39 ± 7
4 (emodin, 40 mg/kg)	8	38 ± 4
5 (emodin, 80 mg/kg)	9	36 ± 5a

^aP < 0.05 vs group 2.s

Table 4 Immunochemistry results in different groups (percentage of TGF-β₁ positive cells)

Group	n	0	+	+2	+3	+4
1 (Normal)	10	9	1	0	0	0
2 (Control)	8	0	0	0	4	4
3 (emodin, 20 mg/kg)	8	0	0	4	4	0
4 (emodin, 40 mg/kg)	8	0	4	3	1	0
5 (emodin, 80 mg/kg)	9	4	5	0	0	0

0: No; +: 0%-25%; + 2: 25%-50%; + 3: 50%-75%; + 4: > 75%.