Optimal biliary drainage for inoperable Klatskin's tumor based on Bismuth type

Table 1 Demographics and clinical outcome of patients according to Bismuth type

	Bismuth II	Bismuth III	Bismuth IV	P value
Number of patients	21	47	66
Age (yr)1	68.9 ± 2.4	67.5 ± 1.4	66.6 ± 1.3	0.66
Sex (M:F)	16:5	31:16	46:20	0.74
Serum bilirubin (mg/dL)1	9.55 ± 1.66	14.06 ± 1.27	12.69 ± 0.93	0.10
ERBD:EPTBD:IPTBD	6:8:7	12:23:12	16:35:15	0.74
Palliation of cholestasis	21 (100%)	43 (91.5%)	7 (88%)	0.30
Patency (d)1	103 ± 17	98 ± 12	113 ± 15	0.85
Patency (d)2	92 (32-152)	65 (35-95)	81 (55-107)
Procedure related cholangitis	5 (23.8%)	12 (25.5%)	12 (18.2%)	0.58
Procedure related pancreatitis	0 (0%)	2 (4.3%)	0 (0%)	0.15
Procedure related bleeding	1 (4.8%)	5 (10.6%)	6 (9.1%)	0.79
Procedure related mortality	0	0	0	1.00
30-d mortality	0 (0%)	1 (2.1 %)	1 (1.5%)	1.00

¹Values expressed as mean ± SE.

²Values expressed as median (range).

Table 2 Demographics and clinical outcome of patients according to drainage procedure

	ERBD	PTBD	PTBDS	P value
Number of patients	34	66	34
Age (yr)1	66.8 ± 2.9	67.2 ± 1.1	67.9 ± 1.8	0.91
Sex (M:F)	23:11	46:20	24:10	0.97
Bismuth type(II:III:IV)	6:12:16	8:23:35	7:12:15	0.81
Serum bilirubin (mg/L)1	9.62 ± 1.14	14.89 ± 1.10	11.47 ± 1.09	< 0.01
Palliation of cholestasis	27 (79.4%)	62 (93.9%)	33 (97.1%)	0.03
Patency (d)1	120 ± 16	59 ± 6	180 ± 20	< 0.01
Patency (d)2	97 (67-127)	49 (27-71)	167 (122-217)
Procedure related cholangitis	10 (29.4%)	8 (12.1%)	11 (32.4%)	0.03
Procedure related pancreatitis	1 (2.9%)	0 (0%)	1 (2.9%)	0.26
Procedure related bleeding	2 (5.9%)	5 (7.6%)	5 (14.7%)	0.50
Procedure related mortality	0	0	0	1.00
30-d mortality	0 (0%)	1 (2.1%)	1 (1.5%)	0.26

¹Values expressed as mean ± SE.

²Values expressed as median (range).

Table 3 Comparison of demographics and clinical outcome of patients according to number of stents

	Unilateral	Bilateral	P value
Number of patients	89	45
Age (yr)1	67.3 ± 1.0	67.2 ± 1.7	0.95
Sex (M:F)	63:26	30:15	0.77
Bismuth type (II:III:IV)	12:30:47	9:17:19	0.44
Drainage method (ERBD:EPTBD:IPTBD)	27:48:14	7:18:20	< 0.01
Type of stent (EPTBD:Plastic:Metal)	48:25:16	18:23:04	0.03
Serum bilirubin (mg/dL) (mg/L)1	12.42 ± 0.90	13.22 ± 7.29	0.59
Palliation of cholestasis	80 (89.9%)	42 (93.3%)	0.73
Patency (d)1	88 ± 9	136 ± 16	0.01
Patency (d)2	68 (45-91)	112 (35-189)
Procedure related cholangitis	17 (19.1%)	12 (26.7%)	0.43
Procedure related pancreatitis	1 (1.1%)	1 (2.3%)	0.61
Procedure related bleeding	6 (6.7%)	6 (13.3%)	0.34
Procedure related mortality	0	0	1.00
30-d mortality	2 (2.3%)	0 (0%)	0.79

¹Values expressed as mean ± SE.

²Values expressed as median (range).

Table 4 Comparison of clinical characteristics and clinical outcome according to drainage method in Bismuth type IIIpatients

	ERBD	EPTBD	IPTBD	P value
Number of patients	12	23	12
Age (yr)1	67.4 ± 3.1	67.0 ± 2.1	68.7 ± 2.5	0.89
Sex (M:F)	7:5	15:8	9:3	0.67
Stent number1	1.1 ± 0.1	1.1 ± 0.1	1.7 ± 0.1	< 0.01
Serum bilirubin (mg/dL)1	10.72 ± 1.81	16.91 ± 2.14	11.13 ± 1.81	0.07
Palliation of cholestasis	9 (75%)	22 (95.7%)	12 (100%)	0.12
Patency (d)1	188 ± 47	53 ± 8	133 ± 21	< 0.01
Patency (d)2	163 (20-306)	47 (7-87)	145 (142-148)
Procedure related cholangitis	5 (41.7%)	2 (8.7%)	5 (41.7%)	0.03
Procedure related pancreatitis	1 (8.3%)	0 (0 %)	1 (8.3%)	0.26
Procedure related bleeding	0 (0%)	2 (8.7%)	3 (25%)	0.14
Procedure related mortality	0	0	0	1.00
30-d mortality	1 (8.3%)	0 (0%)	0 (0%)	0.51

¹Values expressed as mean ± SE.

²Values expressed as median (range).

Table 5 Comparison of demographics and clinical outcome according to drainage method in Bismuth type IV patients

	ERBD	EPTBD	IPTBD	P value
Number of patients	16	35	15
Age (yr)1	64.6 ± 3.6	67.1 ± 1.5	67.6 ± 2.5	0.68
Sex (M:F)	12:4	24:11	10:5	0.88
Stent number1	1.1 ± 0.1	1.1 ± 0.4	1.6 ± 0.6	0.01
Serum bilirubin (mg/dL)1	10.46 ± 1.75	13.99 ± 1.32	12.08 ± 1.86	0.29
Palliation of cholestasis	12 (75%)	32 (93.4%)	14 (93.3%)	0.28
Patency (d)1	102 ± 19	60 ± 9	251 ± 36	< 0.01
Patency (d)2	90 (69-111)	43 (21-65)	280 (171-389)
Procedure related cholangitis	3 (18.8%)	4 (11.4%)	5 (33.3%)	0.16
Procedure related pancreatitis	0 (0%)	0 (0%)	0 (0%)	1.00
Procedure related bleeding	1 (6.3%)	3 (8.6%)	2 (13.3%)	0.55
Procedure related mortality	0	0	0	1.00
30-d mortality	0 (0%)	0 (0%)	1 (1.5%)	0.23

¹Values expressed as mean ± SE.

²Values expressed as median (range).