Molecular mechanism of immune response induced by foreign plasmid DNA after oral administration in mice

Table 1 A global view of differential gene expression

Categories	Number of up-regulatedgenes		Number of down-regulatedgenes
	4 h	18 h	4 h	18 h
|SLR| <  1	1527	1225	131	73
|SLR| ≥ 1	276	395	447	70
|SLR| ≥ 2	64	188	92	17
|SLR| ≥ 3	21	95	60	10
|SLR| ≥ 4	4	32	27	7
Total	1803	1620	578	143

Table 2 Levels of sIL-2R, ALT, and HBV DNA in the sera of patients with chronic HBV infection (mean  ±  SD)

Probe set	Gene symbol	4 h (SLR)	18 h(SLR)	Gene title
1423754_at	1110004C05Rik	0.9	0.8	RIKEN cDNA 1110004C05 gene
1425156_at	9830147J24Rik	0.4	1.6	RIKEN cDNA 9830147J24 gene
1452428_a_at	B2m	0.5	0.4	beta-2 microglobulin
1418021_at	C4	0.3	0.3	Complement component 4 (within H-2S)
1418126_at	Ccl5	0.3	0.3	Chemokine (C-C motif) ligand 5
1419609_at	Ccr1	1.1	0.4	Chemokine (C-C motif) receptor 1
1418930_at	Cxcl10	0.3	1.2	Chemokine (C-X-C motif) ligand 10
1417876_at	Fcgr1	1.5	0.4	Fc receptor, IgG, high affinity I
1431591_s_at	G1p2	1.7	1.6	interferon, alpha-inducible protein
1420549_at	Gbp1	0.6	0.7	Guanylate nucleotide binding protein 1
1435906_x_at	Gbp2	0.7	0.2	Guanylate nucleotide binding protein 2
1421596_s_at	H28	1.9	1.4	Histocompatibility 28
1425917_at	H28	1.5	1.8	Histocompatibility 28
1451721_a_at	H2-Ab1	0.3	0.2	Histocompatibility 2, class II antigen A, beta 1
1426324_at	H2-D1	0.7	0.7	Histocompatibility 2, D region locus 1
1424948_x_at	H2-K	0.3	0.6	Histocompatibility 2, K region
1425336_x_at	H2-K	0.3	0.3	Histocompatibility 2, K region
1452544_x_at	H2-K	0.5	0.3	Histocompatibility 2, K region
1421358_at	H2-M3	0.5	0.2	Histocompatibility 2, M region locus 3
1449875_s_at	H2-T10	0.6	0.4	histocompatibility 2, T region locus 10
1449556_at	H2-T23	0.3	0.2	Histocompatibility 2, T region locus 23
1419603_at	Ifi16	4.6	4.2	Interferon, gamma-inducible protein 16
1421551_s_at	Ifi202b	1.5	0.9	Interferon activated gene 202B
1452348_s_at	Ifi205	0.5	0.4	Interferon activated gene 205
1452349_x_at	Ifi205	0.8	0.7	Interferon activated gene 205
1450783_at	Ifit1	0.8	0.6	Interferon-induced protein with tetratricopeptide repeats 1
1449025_at	Ifit3	1.1	0.8	Interferon-induced protein with tetratricopeptide repeats 3
1418219_at	Il15	1.6	1.4	Interleukin 15
1416296_at	Il2rg	0.5	0.6	Iinterleukin 2 receptor, gamma chain
1449399_a_at	Il1b	0.9	0.4	Interleukin 1 beta
1421322_a_at	Isgf3g	0.3	0.4	Iinterferon-dependent positive acting transcription factor 3 gamma
1425436_x_at	Klra3	0.7	0.1	Killer cell lectin-like receptor, subfamily A, member 3
1417185_at	Ly6a	0.9	0.9	Lymphocyte antigen 6 complex, locus A
1421571_a_at	Ly6c	0.7	0.3	Lymphocyte antigen 6 complex, locus C
1416930_at	Ly6d	0.6	0.5	Lymphocyte antigen 6 complex, locus D
1422089_at	Ncr1	1.4	1.0	Natural cytotoxicity triggering receptor 1
1453196_a_at	Oasl2	2.1	1.9	2'-5' oligoadenylate synthetase-like 2
1422962_a_at	Psmb8	0.4	0.3	Proteosome (prosome, macropain) subunit, beta type 8 (large multifunctional protease 7)
1450696_at	Psmb9	0.8	0.6	Proteosome (prosome, macropain) subunit, beta type 9 (large multifunctional protease 2)
1417056_at	Psme1	0.5	0.4	Proteasome (prosome, macropain) 28 subunit, alpha
1418131_at	Samhd1	0.6	0.2	SAM domain and HD domain, 1
1421812_at	Tapbp	0.3	0.5	TAP binding protein
1425324_x_at	Igh-4	-1.7	-2.1	Immunoglobulin heavy chain 4 (serum IgG1)
1429381_x_at	Igh-VJ558	-1.2	-1.4	Immunoglobulin heavy chain (J558 family)
1451632_a_at	Igh-1	-2	-2.5	Immunoglobulin heavy chain 1 (serum IgG2a)