COX-2 expression in gastric cancer and its relationship with angiogenesis using tissue microarray

Table 1 Expression of COX-2 protein in the gastric cancer and normal mucosa

Variable	n	COX-2 expression		COX-2-positive rate (%)	χ2	P
		-	+ - +++
Tissue character					12.191	0.000
Normal mucosa	37	15	22	59.46
Gastric cancer	87	11	76	87.36
Histologic type					5.391	0.495
Papillary adenocarcinoma	2	0	2	100.00
Well-differentiated adenocarcinoma	8	2	6	75.00
Moderately-differentiated adenocarcinoma	28	4	24	85.71
Poorly-differentiated adenocarcinoma	29	2	27	91.10
Mucin adenocarcinoma	12	0	12	100.00
Signet-ring cell carcinoma	5	1	4	80.00
Undifferentiated carcinoma	2	1	1	50.00
Metastasis					5.502	0.019
Negative	21	6	15	71.43
Positive	66	5	61	92.42
Depth of invasion					6.315	0.043
Muscle invasion	3	0	3	10.00
Subserosa invasion	68	20	48	70.59
Serosa exposure invasion	23	2	21	91.30
Borrman type					2.228	0.328
Borrman II	7	0	7	100.00
Borrman III	85	9	76	89.41
Borrman IV	4	1	3	75.00

Table 2 MVD in the gastric cancer and normal mucosa (mean ± SD)

Variable	n	MVD	t/F	P
Tissue character			7.53	0.000
Normal mucosa	38	36.21 ± 18.47
Gastric cancer	92	65.49 ± 20.64
Histologic type			3.68	0.003
Papillary adenocarcinoma	2	39.50 ± 7.78
Well-differentiated adenocarcinoma	9	42.56 ± 20.35
Moderately-differentiated adenocarcinoma	28	56.79 ± 20.97
Poor-differentiated adenocarcinoma	31	72.65 ± 20.49
Mucin adenocarcinom	14	63.64 ± 23.02
Signet-ring cell carcinoma	5	74.40 ± 33.56
Undifferentiated carcinoma	3	44.67 ± 20.23
Histologic type			4.83	0.000
Moderately or well-differentiated	39	54.68 ± 19.78
Poorly or undifferentiated	53	73.88 ± 17.25
Metastasis			4.214	0.043
Negative	26	54.08 ± 24.42
Positive	66	65.08 ± 22.63
Organ metastasis			1.14	0.355
Lymph nodes metastasis	66	65.08 ± 22.63
Liver metastasis	4	82.00 ± 10.61
Ovary metastasis	1	100
Peritoneal metastasis	9	68.44 ± 26.16
Depth of invasion			0.583	0.627
Muscle invasion	4	68.00 ± 19.13
Subserosa invasion	63	60.33 ± 24.28
Serosa exposure invasion	24	65.96 ± 22.68
Borrman type			0.459	0.634
Borrman II	7	55.71 ± 17.17
Borrman III	79	62.92 ± 23.89
Borrman IV	6	61.97 ± 23.55

Table 3 Correlation between COX-2 protein expression and MVD in gastric cancer

	Degree of staining	MVD	t	P
COX-2-negative	-	25.82 ± 7.76	13.12	0.000
COX-2-positive	+ - +++	68.59 ± 19.8