Comparison of three different recombinant hepatitis B vaccines: GeneVac-B, Engerix B and Shanvac B in high risk infants born to HBsAg positive mothers in India

Table 1 Adverse effects reported by infant vaccinees in GeneVac-B, Engerix B and Shanvac B groups n (%)

Symptoms	GeneVac-B (48)	Engerix B (38)	Shanvac B (32)
Mild fever	4 (8.3)	3 (7.8)	3 (9.3)
Moderate fever	3 (6.2)	2 (5.2)	2 (6.2)
Excessive crying	1 (2)	1 (2.6)	1 (3.1)
Irritability	2 (4.1)	1 (2.6)	1 (3.1)
Local swelling	2 (4.1)	3 (6.8)	2 (6.2)
Local erythema	2 (4.1)	2 (5.2)	2 (6.2)
Induration	1 (2)	1 (2.6)	1 (3.1)
Rash	1 (2)	nil	1 (3.1)

Table 2 Immunogenicity data of GeneVac-B, Engerix B and Shanvac B in babies born to HBsAg positive mothers

Parameters	1st dose	2nd dose	3rd dose	After one year
Group-I- GeneVac-B
No. of infants	58	48	48	35
Seroconversion	57.10%	94.20%	100%	100%
Seroprotection	22.80%	82.80%	100%	100%
GMT (mIu/mL)	11.6	35.4	93.5	226.7
Group-II- Engerix B
No. of infants	50	43	38	21
Seroconversion	57.10%	90.00%	100%	100%
Seroprotection	19.00%	71.40%	100%	100%
GMT (mIu/mL)	8.4	24.4	80.9	197.9
Group-III Shanvac B
No. of infants	50	45	32	12
Seroconversion	50%	91.60%	100%	100%
Seroprotection	16.60%	66.60%	100%	100%
GMT (mIu/mL)	8	18.6	72.55	173.6