Assessment of health-related quality of life in Chinese patients with minimal hepatic encephalopathy

Table 1 Demographic and clinical data of different study groups

	Control subjects(n = 160)	Chronic hepatitis B(n = 20)	Cirrhosis(n = 106)
Age	44.8 ± 7.1	43.2 ± 6.3	45.4 ± 7.2
Gender M/F	115/45	6/14	73/33
Educational level, yr	11.7 ± 2.5	12.3 ± 2.7	11.3 ± 2.3
Child-Pugh class	-	-	A 28/B 64/C 14
MHE (+/-)	-	-	33/73
ALT (U/L)	25.4 ± 8.0	89.4 ± 32.5	48.2 ± 23.6

Table 2 Comparison of health related quality of life in different study groups as assessed by the SF-36 and CLDQ questionnaires

Domains	Control(n = 160)	Chronichepatitis B(n = 20)	Cirrhosis (n = 106)			Cirrhosis (n = 106)		Pearsonitem-scalecorrelations(n = 23)	Internal reliabilitycoefficients(Cronbach's α)(n = 106)
			Child-Pugh A(n = 28)	Child-Pugh B(n = 64)	Child-Pugh C(n = 14)	Non-MHE(n = 73)	MHE(n = 33)
SF-36
PF	96.9 ± 4.5	86.3 ± 11.0a	63.0 ± 15.8a	50.4 ± 17.0ab	43.6 ± 13.4ab	59.9 ± 14.2a	37.1 ± 13.1ad	0. 92	0.85
RP	86.6 ± 18.4	68.8 ± 21.3a	50.9 ± 24.0a	28.9 ± 26.1ab	10.7 ± 18.9abe	40.8 ± 27.5a	15.2 ± 19.7ad	0.83	0.86
BP	90.1 ± 12.5	78.9 ± 14.4a	71.0 ± 13.6a	58.0 ± 19.7ab	59.5 ± 18.3ab	66.8 ± 16.5a	50.2 ± 18.9ad	0.72	0.80
GH	89.0 ± 5.7	60.8 ± 10.5a	46.1 ± 16.5a	25.9 ± 15.7ab	18.2 ± 13.1ab	34.8 ± 18.8a	20.0 ± 12.3ad	0.78	0.73
VT	87.5 ± 4.3	70.8 ± 8.6a	61.1 ± 17.4a	45.5 ± 19.4ab	32.1 ± 11.6abe	55.1 ± 19.1a	31.8 ± 11.0ad	0.82	0.71
SF	95.8 ± 7.1	76.1 ± 12.6a	67.1 ± 18.0a	50.3 ± 17.1ab	44.4 ± 18.5ab	61.5 ± 16.7a	37.4 ± 13.0ad	0.71	0.67
RE	88.5 ± 15.9	50.0 ± 22.9a	51.2 ± 21.2a	22.4 ± 23.8ab	14.3 ± 17.1ab	35.2 ± 26.0a	15.2 ± 20.6ad	0.90	0.86
MH	88.7 ± 5.2	72.2 ± 10.6a	64.4 ± 11.6a	48.3 ± 17.5ab	37.1 ± 13.1ab	56.0 ± 17.5a	40.2 ± 13.2ad	0.82	0.78
CLDQ
AS	6.7 ± 0.5	5.5 ± 1.0a	5.2 ± 1.1a	4.5 ± 1.2ab	4.1 ± 1.1ab	4.9 ± 1.2a	4.1 ± 1.0ad	0.81	0.87
FA	6.1 ± 0.6	4.5 ± 1.0a	4.3 ± 1.2a	3.8 ± 1.2ac	3.5 ± 1.1ab	4.0 ± 1.2a	3.6 ± 1.2a	0.83	0.94
SS	6.3 ± 0.6	5.2 ± 1.1a	5.2 ± 1.2a	4.7 ± 1.3a	4.4 ± 1.2ac	4.9 ± 1.3a	4.6 ± 1.1a	0.87	0.81
AC	6.5 ± 0.5	5.3 ± 0.9a	5.0 ± 1.2a	4.7 ± 1.3a	4.4 ± 1.3a	4.9 ± 1.3a	4.5 ± 1.2a	0.88	0.75
EF	6.3 ± 0.5	4.8 ± 0.9a	4.8 ± 1.0a	4.7 ± 1.0a	4.6 ± 1.0a	4.8 ± 1.0a	4.6 ± 1.1a	0.82	0.89
WO	6.8 ± 0.4	4.9 ± 1.0a	4.8 ± 1.0a	4.3 ± 1.1ac	4.2 ± 1.1a	4.5 ± 1.1a	4.2 ± 1.0a	0.78	0.88

PF: physical functioning; RP: role-physical; BP: body pain; GH: general health; VT: vitality; SF: social functioning; RE: role-emotion; MH: mental health; AS: abdominal symptoms; FA: fatigue; SS: systemic symptoms; AC: activity; EF: emotional function; WO: worry.

^aP < 0.01 vs control group;

^bP < 0.01,

^cP < 0.05 vs Child-Pugh A;

^eP < 0.05 vs Child-Pugh B;

^dP < 0.01 vs non-MHE.