Significance of platelet activating factor receptor expression in pancreatic tissues of rats with severe acute pancreatitis and effects of BN52021

Table 1 Scoring standard of pathological changes in rat pancreatic tissues with SAP

Pathological	Pathological	Scores
grading	change
Edema	Inter-lobule local edema, widened pleura	1
	Inter-lobule diffuse edema, widened intra-lobule
	clearance	2
	Increased intra-lobule clearance, alveolus swollen,
	and separated	3
Inflammatory	White cells < 20/visual field under high-power
	microscope	1
	White cells 20-50/visual field under
	high-power microscope	2
	White cells > 30/visual field under high-power
	microscope, or micro-abscess occurs	3
Hemorrhage	Parenchymal hemorrhage < 20%	1
	Parenchymal hemorrhage 20%-50%	2
	Parenchymal hemorrhage > 50%	3
Necrosis	Necrosis area < 20%	1
	Necrosis area 20%-50%	2
	Necrosis area > 50%	3

Table 2 Serum amylase level at different time points in each group after operation (n = 10, mean ± SD, U/L)

Groups	Time phase points (h)
	1	2	3	6	12	24
NC	1835.6	1491.5	1530.4	1400.2	2153.2	1337
	± 613.2	± 507.0	± 247.0	± 447.5	± 236.3	± 243.7
SAP	2560.5	2810.5	4799.3	4919.7	3486.3	2283
	± 121.5a	± 147.2a	± 107.0a	± 139.6a	± 181.8a	± 127.0a
BN	2214.5	3331.7	4185	3784.7	3454	1360.4
	± 109.1a	± 196.4a	± 147.8ab	± 124.1ab	± 264.1a	± 161.4b

^aP < 0.05 vs NC group;

^bP < 0.05 vs SAP group.

Table 3 Scores of pancreatic tissues at different time points in each group after operation (n = 10, mean ± SD)

Groups	Time phase points (h)
	1	2	3	6	12	24
NC	0.12 ± 0.05	0.11 ± 0.06	0.12 ± 0.05	0.13 ± 0.04	0.12 ± 0.06	0.13 ± 0.05
SAP	4.82 ± 0.35a	7.65 ± 0.40a	8.85 ± 0.39a	9.15 ± 0.55a	10.10 ± 0.65a	11.75 ± 0.25a
BN	5.55 ± 0.30a	6.65 ± 0.42a	5.95  ± 0.19ab	5.55 ± 0.36ab	6.72 ± 0.30ab	9.95 ± 0.58a

^aP < 0.05 vs NC group;

^bP < 0.05 vs SAP group.

Table 4 Absorbance values of PAF-R mRNA in pancreatic tissues at various time points in each group after operation (n = 10, mean ± SD)

Groups	Time phase points (h)
	1	2	3	6	12	24
NC	0.46	0.48	0.47	0.47	0.46	0.43
	± 0.10	± 0.10	± 0.10	± 0.09	± 0.10	± 0.09
SAP	0.49	0.54	0.71	0.38	0.25	0.20
	± 0.09	± 0.14	± 0.14a	± 0.08a	± 0.07a	± 0.06a
BN	0.49	0.51	0.69	0.59	0.29	0.20
	± 0.05	± 0.07	± 0.13a	± 0.04a	± 0.05a	± 0.04a

^aP < 0.05 vs NC group.

Table 5 Absorbance values of PAF-R protein in pancreatic tissues at various time points in each group after operation (n = 10, mean ± SD)

Groups	Time phase points (h)
	1	2	3	6	12	24
NC	0.44 ± 0.02	0.48 ± 0.02	0.48 ± 0.03	0.49 ± 0.09	0.52 ± 0.08	0.49 ± 0.10
SAP	0.53 ± 0.03	0.90 ± 0.02a	1.69 ± 0.06a	1.12 ± 0.10a	1.04 ± 0.14a	0.97 ± 0.16a
BN	0.43 ± 0.06	0.80 ± 0.05a	1.58 ± 0.02a	0.98 ± 0.03a	0.87 ± 0.02a	0.90 ± 0.05a

^aP < 0.05 vs NC group.