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©2007 Baishideng Publishing Group Co.
World J Gastroenterol. May 28, 2007; 13(20): 2803-2810
Published online May 28, 2007. doi: 10.3748/wjg.v13.i20.2803
Published online May 28, 2007. doi: 10.3748/wjg.v13.i20.2803
Table 1 Correlation of NDRG1 expression with clinicopathologic variables in Japanese cases
Total cases (%) | Positive | Negative | P value | |
n = 80 | n = 55 | n = 25 | ||
Age (yr) | 0.622 | |||
> 66 | 48 (60.0) | 34 | 14 | |
< 66 | 32 (40.0) | 21 | 11 | |
Gender | 0.649 | |||
Male | 45 (56.3) | 30 | 15 | |
Female | 35 (43.7) | 25 | 10 | |
Tumor location | 0.164 | |||
Right-hemicolon | 28 (35.0) | 22 | 6 | |
Left-hemicolon | 52 (65.0) | 33 | 19 | |
Histopathological Type | 0.067 | |||
Well | 39 (48.8) | 22 | 17 | 0.017 |
Moderate | 38 (47.6) | 31 | 7 | |
Poor | 1 (1.2) | 1 | 0 | |
Mucinous | 1 (1.2) | 1 | 0 | |
Sig | 1 (1.2) | 0 | 1 | |
Dukes’ stage | 0.036 | |||
A | 22 (27.5) | 11 | 11 | |
B | 21 (26.3) | 14 | 7 | |
C | 27 (33.7) | 20 | 7 | |
D | 10 (12.5) | 10 | 0 | |
Liver metastasis | 0.062 | |||
Negative | 73 (91.3) | 48 | 25 | |
Positive | 7 (8.7) | 7 | 0 | |
Lymph node metastasis | 0.14 | |||
Negative | 48 (60.0) | 30 | 18 | |
Positive | 32 (40.0) | 25 | 7 | |
Lymphatic invasion | 0.021 | |||
Negative | 19 (23.8) | 9 | 10 | |
Positive | 61 (76.2) | 46 | 15 | |
Venous invasion | 0.0077 | |||
Negative | 15 (18.8) | 6 | 9 | |
Positive | 65 (81.2) | 49 | 16 | |
Depth of invasion | 0.01 | |||
m | 5 (6.3) | 1 | 4 | |
sm | 8 (10.0) | 4 | 4 | |
mp | 14 (17.5) | 10 | 4 | |
ss, a1 | 29 (36.3) | 23 | 6 | |
se, a2 | 23 (28.7) | 16 | 7 | |
si, ai | 1 (1.2) | 1 | 0 |
Table 2 Correlation of NDRG1 expression with clinicopathologic variables in U.S. (Caucasian and African American) cases
All U.S. cases (n = 77) | Caucasian (n = 43) | African American (n = 34) | ||||||||||
NDRG1 | NDRG1 | NDRG1 | ||||||||||
Total (%) | + | - | P value | Total (%) | + | - | P value | Total (%) | + | - | P value | |
Age (yr) | 0.079 | 0.092 | 0.464 | |||||||||
> 66 | 45 (58.4) | 19 | 26 | 26 (60.5) | 10 | 16 | ||||||
< 66 | 32 (41.6) | 20 | 12 | 17 (39.5) | 11 | 6 | 19 (55.9) | 9 | 10 | |||
Gender | 0.074 | 0.255 | 15 (44.1) | 9 | 6 | 0.153 | ||||||
Male | 58 (75.3) | 26 | 32 | 32 (74.4) | 14 | 18 | ||||||
Female | 19 (24.7) | 13 | 6 | 11 (25.6) | 7 | 4 | 26 (76.5) | 12 | 14 | |||
Histopathological type | 0.31 | 0.21 | 8 (23.5) | 6 | 2 | 0.18 | ||||||
Well | 47 (61.0) | 20 | 27 | 0.15a | 28 (65.1) | 11 | 17 | 0.049a | 0.88a | |||
Moderate | 23 (29.9) | 14 | 9 | 14 (32.6) | 10 | 4 | 19 (55.9) | 9 | 10 | |||
Poor | 2 (2.6) | 1 | 1 | 0 (0) | 0 | 0 | 9 (26.5) | 4 | 5 | |||
Mucinous | 5 (6.5) | 4 | 1 | 1 (2.3) | 0 | 1 | 2 (5.9) | 1 | 1 | |||
Dukes’ stage | 0.056 | 0.0063 | 4 (11.8) | 4 | 0 | 0.88 | ||||||
A | 7 (9.1) | 1 | 6 | 4 (9.3) | 0 | 4 | ||||||
B | 28 (36.4) | 14 | 14 | 16 (37.2) | 8 | 8 | 3 (8.8) | 1 | 2 | |||
C | 23 (29.9) | 16 | 7 | 14 (32.6) | 11 | 3 | 12 (35.3) | 6 | 6 | |||
D | 19 (24.6) | 8 | 11 | 9 (20.9) | 2 | 7 | 9 (26.5) | 5 | 4 | |||
Liver metastasis | 0.39 | 0.072 | 10 (29.4) | 6 | 4 | 0.59 | ||||||
Negative | 58 (75.3) | 31 | 27 | 34 (79.1) | 19 | 15 | ||||||
Positive | 19 (24.7) | 8 | 11 | 9 (20.9) | 2 | 7 | 24 (70.6) | 12 | 12 | |||
Lymph node metastasis | 0.212 | 0.28 | 10 (29.4) | 6 | 4 | 0.52 | ||||||
Negative | 35 (45.5) | 15 | 20 | 20 (46.5) | 8 | 12 | 15 (44.1) | 7 | 8 | |||
Positive | 42 (54.5) | 24 | 18 | 23 (53.5) | 13 | 10 | 19 (55.9) | 11 | 8 |
Table 3 Frequency of expression of p53 and HIF-1α in Japanese and U.S. patients n (%)
p53 | HIF-1α | |||
Positive | Negative | Positive | Negative | |
Japanese (n = 80) | 43 (54.0) | 37 (46.0) | 42 (52.5) | 38 (47.5) |
All U.S. cases (n = 77) | 48 (62.3) | 29 (37.7) | 18 (23.4) | 59 (76.6) |
Caucasian (n = 43) | 28 (65.1) | 15 (34.9) | 13 (30.2) | 30 (69.8) |
African American (n = 34) | 20 (58.8) | 14 (41.2) | 5 (14.7) | 29 (85.3) |
Table 4 Correlation of expression of NDRG1 with p53 and HIF-1α
NDRG1 | P value | |||
Positive | Negative | |||
Japanese (n = 80) | ||||
p53 | + | 31 | 12 | 0.49 |
- | 24 | 13 | ||
HIF-1α | + | 25 | 17 | 0.061 |
- | 30 | 8 | ||
All U.S. cases (n = 77) | ||||
p53 | + | 28 | 20 | 0.083 |
- | 11 | 18 | ||
HIF-1α | + | 13 | 5 | 0.036 |
- | 26 | 33 | ||
Caucasian (n = 43) | ||||
p53 | + | 16 | 12 | 0.14 |
- | 5 | 10 | ||
HIF-1α | + | 10 | 3 | 0.015 |
- | 11 | 19 | ||
African American (n = 34) | ||||
p53 | + | 12 | 8 | 0.32 |
- | 6 | 8 | ||
HIF-1α | + | 3 | 2 | 0.73 |
- | 15 | 14 |
- Citation: Koshiji M, Kumamoto K, Morimura K, Utsumi Y, Aizawa M, Hoshino M, Ohki S, Takenoshita S, Costa M, Commes T, Piquemal D, Harris CC, Tchou-Wong KM. Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity. World J Gastroenterol 2007; 13(20): 2803-2810
- URL: https://www.wjgnet.com/1007-9327/full/v13/i20/2803.htm
- DOI: https://dx.doi.org/10.3748/wjg.v13.i20.2803