Comparison of early enteral nutrition in severe acute pancreatitis with prebiotic fiber supplementation versus standard enteral solution: A prospective randomized double-blind study

Table 1 Demographic features and baseline biochemical, prognostic indices in study and control groups

	Study group(n = 15)	Control group(n = 15)	P
Mean age (SD)	47.3 (16.8)	44.9 (11.2)	NS
Sex (Male:Female)	6:9	8:7	NS
Body mass index mean (SD)	24.7 (7.8)	27.1 (9.5)	NS
Interval between onset of symptoms and admission (days) median (range)	2 (1-9)	1 (1-6)	NS
Etiology (n, %)
Biliary	11 (73.3)	12 (80)	NS
Post-ERCP	2 (13.3)	2 (13.3)	NS
Hyperlipidemia	1 (6.6)	1 (6.6)	NS
Idiopathic	1 (6.6)	0 (0)	NS
At admission
Serum amylase, mean (SD) IU/L	545 (232)	498 (277)	NS
Serum lipase, mean (SD) IU/L	554 (167)	396 (187)	NS
Serum CRP, mean (SD) mg/L	232 (97)	244 (104)	NS
Serum prealbumin, mean (SD) mg/L	17.6 (4.5)	19.1 (6.7)	NS
APACHE II score, mean (SD)	9.4 (3.7)	9.6 (3.8)	NS
Balthazar CT score, mean (SD)	8.5 (4.6)	9.1 (5.2)	NS

ERCP: endoscopic retrograde cholangiopancreaticography; CRP: C-reactive protein; CT: computerized tomography; SD: standard deviation; NS: not significant.

Table 2 Clinical course of patients in the study and control groups

	Study group	Control group	P
Median duration of hospital stay ± (range)	10 ± 4 (8-14)	15 ± 6 (7-26)	< 0.05
Median value of days in ICU ± (range)	6 ± 2 (5-8)	6 ± 2 (5-7)	NS
Median duration of EN ± (range)	8 ± 4 (6-12)	10 ± 4 (6-13)	NS
Median duration (days) of serum amylase or lipase normalization ± (range)	7 ± 2 (6-9)	8 ± 3 (6-11)	NS
Complications
Multiorgan failure (n)	1	2
Cholangitis (n)	1	0
Sepsis (n)	1	2
Pseudocyst (n)	2	1
Number of deaths (n)	2	4
Overall complications (%)	7/15 (46.6)	9/15 (60%)	< 0.05

ICU: intensive care unit; EN: enteral nutrition; NS: not significant.

Table 3 Time (days) for normalization of CRP, APACHE II and CT scores in the study and control groups, (mean ± SD)¹

Items	Study group	Control group	P
CRP mg/L	7 ± 2	10 ± 3	< 0.05
APACHE II score	4 ± 2	6.5 ± 3	< 0.05
CT score	12 ± 4	16 ± 3	< 0.05

¹Normal values: APACHE II < 8, CT score = 0-1, CRP negative. CRP: C-reactive protein; CT: computerized tomography.