Iron deposition and fat accumulation in dimethylnitrosamine-induced liver fibrosis in rat

Table 1 Changes of serum ALT and tissue Hyp means ± SD

Group	n	ALT (U/mL)	Hyp (μg/g)
Control	10	20.8 ± 4.96	109.14 ± 29.06
Model A	10	60.2 ± 8.01b	351.46 ± 65.86b
Model B	12	58 ± 10.32ab	367.37 ± 42.06ab

Statistical method: Nemenyi method.

^aP > 0.05 vs model A;

^bP < 0.01 vs Control.

Table 2 Histopathological semiquantitative scores of collagen deposition in the liver

Groups	n	0	+1	+2	+3	+4	Staging scores (mean ± SD)
Control	10	10	0	0	0	0	0
Model A	10	0	0	1	1	8	3.70 ± 0.67
Model B	12	0	0	1	2	9	3.67 ± 0.65a

Statistic method: Student’s t test.

^aP > 0.05 vs model B.

Table 3 Histopathological semiquantitative scores of fat deposition in the liver

Groups	n	0	+1	+2	+3	+4	Staging scores (mean ± SD)
Control	3	1	2	0	0	0	0.67 ± 0.58
Model A	3	1	2	0	0	0	0.67 ± 0.58a
Model B	3	0	0	0	2	1	3.33 ± 0.58b

Statistic method: Student’s t test.

^bP < 0.01 vs control group;

^aP > 0.05 vs control group.

Table 4 Histopathological semiquantitative scores of iron deposition in the liver

Groups	n	Iron deposition scores (mean ± SD)
Control	10	0
Model A	10	396.10 ± 32.83
Model B	12	389.92 ± 49.42a

Statistic method: Student’s t test.

^aP > 0.05 vs model B.