Timing of mortality in severe acute pancreatitis: Experience from 643 patients

Table 1 Characteristics of severe acute pancreatitis patients with early (≤ 14 d after admission) and late death (>14 d after admission)

	Early death(n = 44)	Late death(n = 61)	P value
Age, yr (range)	54.7 (34-93)	56.3 (30-84)	0.904
Gender			0.147
Females	32 (72.7%)	36 (59.0%)
Males	12 (27.3%)	25 (41.0%)
Etiology
Biliary	13 (29.5%)	32 (52.5%)	0.019
Alcoholic	13 (29.5%)	11 (18.0%)	0.166
Idiopathic	12 (27.3%)	7 (27.9%)	0.946
Other	6 (13.7%)	1 (1.6%)
Ranson’s score	3.9 (1-9)	4.1 (1-8)	0.676
APACHE-II score	22.4 (9-31)	24.5(11-32)	0.732
BMI, (Kg/m2)	24.5 (18-39)	23.6 (19-48)	0.814
Comorbidity			0.557
No comorbidity	9 (20.5%)	9 (32.1%)
1-2 organ systems	22 (50.0%)	22 (50.0%)
3-4 organ systems	8 (18.2%)	17 (27.9%)
> 4 organ systems	5 (11.3%)	4 (6.6%)

BMI: Body mass index.

Table 2 Pancreatic necrosis and causes of death in severe acute pancreatitis patients with early and late mortality n (%)

Pathology and causeof death	Early deaths	Late deaths	P value
	(n = 44)	(n = 61)
Pathology
Edematous	2 (4.5)	3 (4.9)	0.95
Sterile necrosis	21 (42.7)	14 (23.0)	0.008
Infected necrosis	6 (13.6)	31 (50.8)	< 0.0001
Necrosis without microbiological data	15 (34.2)	13 (21.3)	0.144
Cause of death
MOF	40 (90.9)	9 (14.8)	< 0.0001
Infected necrosis	0 (0.0)	14 (23.0)	0.001
Infected necrosis + MOF	1 (2.3)	22 (36.1)	< 0.0001
Intra-abdominal bleeding	1 (2.3)	12 (19.7)	0.008
Heart failure	2 (4.5)	2 (3.3)	0.738
Cerebral stroke	0 (0.0)	2 (3.3)	0.225

MOF: Multi-organ failure.

Table 3 The incidence of early death in severe acute pancreatitis in this study and in the literature

	Total number	Early death (%)
Renner et al, 1985[8]	405	60
Wilson et al, 1988[15]	126	55.5
Lankisch et al, 1996[17]	37	56.7
Isenmann et al, 2001[19]	36	55.5
Present study	105	42