Significance of hepatitis B virus surface antigen, hepatitis C virus expression in hepatocellular carcinoma and pericarcinomatous tissues

Table 1 Correlation between HAI scores and HBsAg and HCV expressions in HCC and noncancerous tissues

Groups	n	Rate(%)	HAI score in noncancerous tissues
NBNC	6	6	6.67 ± 2.58
HBsAg	66	66	9.80 ± 2.97
HCV	7	7	10.71 ± 4.82ac
BC	21	21	12.62 ± 3.88b

^aP > 0.05 vs the other three groups;

^cP <0.05 vs NBNC group vs HBsAg group;

^bP <0.01 vs NBNC group and HBsAg group. Spearman correlation analysis between HAI scores and expressions of HBsAg and HCV in HCC and noncancerous tissues, r_s = 0.393, t = 4.23, P = 0.0001.

Table 2 Correlation between AFP and expressions of HBsAg and HCV in HCC and noncancerous tissues

Groups	n	AFP negative	AFP positive	Positive rates of AFP(%)	Mean of AFP(ng/mL)	Average sum of ranks
NBNC	6	4	2	33.3	53.3	14.3
HBsAg	66	22	44	66.7	352.6	48.7
HCV	7	3	4	57.1	348.2	50.1
BC	21	3	18	85.7	541.2	66.7

AFP negative means AFP value ≤ 20 ng/mL and AFP positive means AFP value ≥ 20 ng/ mL. Rank-sum test, H = 16.11, P = 0.001; coparation between two groups, P < 0.001. Spearman correlation analysis, r_s = 0.38, t = 4.06, P = 0.0001. chi square test, Fisher probabilities P = 0.0415.

Table 3 Knodell scoring

Periportal Bridging Necrosis	Intralobular degeneration and focal necrosis	Portal inflammation	Fibrosis
0: None	0: None	0: None	0: None
1: Mild	1: Mild	1: Mild	1: Fibrous
	(< 1/3 lobules)	(< 1/3 lobules)	portal expansion
3: Moderate	3: Moderate	3: Moderate	3: Bridging
(< 50% circumference)	(< 2/3 lobules)	(< 2/3 lobules)	fibrosis
4: Marked	4: Marked	4: Marked ,dense	4: Cirrhosis
	(> 2/3 lobules)	(> 2/3 lobules)
5: Moderate
+ bridging
6: Marked
+ bridging
10: Multiple
lobular necrosis

HAI score is the combined score of necrosis, inflammation, and fibrosis.