Sonic hedgehog-Gli1 pathway in colorectal adenocarcinomas

Table 1 Colorectal adenocarcinoma specimens and summary of Shh, Ptch1, Smo Gli1, Sufu, PDGFRα and Hip expression

No	WHOClassification	Differentiation	Age	Gender	Shh-ish	SHH-ihc	Ptch1-ish	PTCH1-ihc	Gli1-ish	PDGFRα-ish	Hip-ish
1	RAC	PD	50	M	+	+	-	+	+	+	-
2	RAC	WD	69	F	-	-	-	-	+-	-	-
3	RAC	PD	60	M	+	+	+	+	+	-	-
4	RAC	MD	69	F	+-	+	-	-	-	-	-
5	CAC	MD	50	F	-	-	-	-	-	-	-
6	RAC	WD	72	M	-	-	+-	+	+-	-	-
7	CAC	MD	60	F	-	-	-	-	-	-	-
8	RAC	MD	27	F	-	-	+-	+	-	-	-
9	RAC	MD	63	M	-	-	-	-	-	-	-
10	CAC	WD	55	M	-	-	-	-	+-	-	-
11	RAC	MD	66	F	-	+	-	-	+	-	-
12	CAC	PD	79	F	+	+	-	-	+	-	-
13	RAC	PD	54	M	-	-	-	-	-	-	-
14	RAC	WD	73	F	-	-	-	-	-	-	-
15	RAC	MD	68	F	+	+	+	+	-	-	-
16	RAC	MD	70	F	-	-	-	-	+-	+	-
17	RAC	MD	68	M	-	-	-	-	+	+	-
18	RAC	MD	67	F	-	-	-	-	-	-	-
19	CAC	PD	68	M	+	+	+	+	+	+	+
20	CAC	PD	48	F	-	+	+-	+	+-	-	-
21	RAC	PD	73	M	+	+	-	+	-	-	-
22	RAC	MD	51	M	-	-	-	-	+	-	-
23	RAC	MD	70	M	+	+	+	+	+	-	+
24	RAC	PD	37	F	+	+	+	+	-	-	+
25	RAC	PD	79	M	+	+	+	+	-	-	+

These data were derived from in situ hybridization (ish) and immunohistochemistry (ihc). + means positive result (ratio of positive cells to cancer cells ≥ 25%), - means negative result (no positive cell or ratio of positive cells to cancer cells ≤ 10%), +- means weakly positive result (10% < ratio of positive cells to cancer cells < 25%); WD: Well differentiated; MD: Moderately differentiated; PD: Poorly differentiated; CAC: Colonic adenocarcinoma; RAC: Rectal adenocarcinoma.