Malignancy and mortality in a population-based cohort of patients with coeliac disease or ‘gluten sensitivity’

Table 1 Number of EMA and AGA positive and negative patients

AGA	+ve EMA	-ve EMA	Not recorded	Total
+ve	275	456	402	1133
-ve	215	7807	4183	12 205
Total	490	8263	4585	13 338

Table 2 Standardised incidence ratio (SIR) of malignancies

	EMA +ve			AGA +ve			AGA +ve, EMA -ve
	n	Expectedn	SIR(95% CI)	n	Expectedn	SIR(95% CI)	n	Expectedn	SIR(95% CI)
All malignancies	24	25.41	0.94 (0.57-1.32)	96	86.13	1.11 (0.89-1.34)	68	37.28	1.82 (1.39-2.26)
All malignancies (> 6 mo after diagnosis)	20	24.26	0.82 (0.46-1.19)	75	86.05	0.87 (0.67-1.07)	52	39.84	1.31 (0.95-1.66)
All malignancies (> 12 mo after diagnosis)	18	24.24	0.74 (0.40-1.09)	67	85.94	0.78 (0.59-0.97)	44	37.15	1.18 (0.83-1.53)
Non-Hodgkin’s lymphoma	2	0.27	7.47 (0.00-17.83)	6	2.59	2.32 (0.46-4.17)	3	0.52	5.76 (0.00-12.28)
Gastrointestinal cancer	4	2.97	1.35 (0.03-2.67)	14	11.70	1.20 (0.57-1.82)	9	5.24	1.72 (0.60-2.84)
Small intestine	1	0.04	23.33 (0.00-69.07)	1	0.14	7.28 (0.00-21.54)	1	0.06	15.51 (0.00-45.90)
Lung cancer	1	2.60	0.39 (0-1.14)	5	9.98	0.50 (0.06-0.94)	4	4.51	0.89 (0.02-1.76)
Breast cancer	4	3.92	1.02 (0.02-2.02)	5	10.53	0.47 (0.06-0.89)	1	4.09	0.24 (0.00-0.72)
Prostate cancer	2	1.12	1.78 (0.00-4.24)	8	6.30	1.27 (0.39-2.15)	3	3.13	0.96 (0.00-2.04)
Liver cancer	2	0.06	31.62 (0.00-75.45)	3	0.60	5.01 (0.00-10.69)	2	0.27	7.48 (0.00-17.86)

Table 3 Standardised mortality ratios (SMR) of all cause and cause-specific mortality

	EMA +ve			AGA +ve			AGA +ve, EMA -ve
	n	Expected n	SMR(95% CI)	n	Expectedn	SMR(95% CI)	n	Expectedn	SMR(95% CI)
All cause mortality	46	26.01	1.77 (1.26-2.28)	234	101.25	2.31 (2.01-2.61)	114	47.25	2.41 (1.97-2.86)
All cause mortality (> 6 mo after diagnosis)	35	25.9	1.35 (0.90-1.80)	184	100.79	1.83 (1.56-2.09)	85	46.91	1.81 (1.43-2.20)
All cause mortality (> 12 mo after diagnosis)	32	25.91	1.24 (0.81-1.66)	165	100.09	1.65 (1.40-1.90)	75	46.59	1.61 (1.25-1.97)
Malignant neoplasms	9	7.05	1.28 (0.44-2.11)	52	32.28	1.61 (1.17-2.05)	27	14.55	1.86 (1.16-2.56)
NHL deaths	2	0.29	6.89 (0.00-16.44)	8	1.12	7.12 (2.18-12.05)	3	0.51	5.88 (0.00-12.53)
Endocrine deaths	1	0.16	6.10 (0.00-18.07)	2	0.24	8.19 (0.00-19.53)	1	0.58	1.73 (0.00-5.14)
Nervous system	1	0.25	3.96 (0.00-11.72)	2	2.92	0.69 (0.00-1.63)	1	2.92	0.34 (0.00-1.01)
Circulatory system	9	12.11	0.74 (0.26-1.23)	42	59.95	0.70 (0.49-0.91)	22	28.65	0.77 (0.45-1.09)
Respiratory system	3	2.67	1.12 (0.00-2.40)	35	25.18	1.39 (0.93-1.85)	2	1.45	1.38 (0.00-3.29)
Digestive system disorders	2	0.58	3.42 (0.00-8.17)	19	4.12	4.61 (2.54-6.68)	10	1.90	5.26 (2.00-8.52)