Value of mink vomit model in study of anti-emetic drugs

Table 1 Effects of emetogens on minks (n = 6, mean±SD)

Emetogens	Dose(mg/kg)	Latency(min)	Retching(n)	Emesis(n)	Vomitingratio
NS	-	-	0	0	0/6
Cisplatin	7.5	92.0 ± 21	91.5 ± 37	12.0 ± 3	6/6
NS	-	-	0	0	0/6
Apomorphine	1.6	39.4 ± 36	28.5 ± 16	5.3 ± 1.9	6/6
NS	-	-	0	0	0/6
Copper sulfate	40	7.0 ± 2.0	29.0 ± 9	8.7 ± 2.3	6/6
Pseudo irradiation	0	-	0	0	0/6
X-ray	18 Gy	17.0 ± 4	19.3 ± 7	10.4 ± 3	5/6

Table 2 Effects of ondansetron or metoclopramide on emesis induced by cisplatin or apomorphine in minks (mean±SD, n=6)

Emetogens	Dose (mg/kg)	Anti-emetics	Dose (mg/kg)	Latency (min)	Retching (n)	Emesis (n)
Cisplatin	7.5	NS		92.0 ± 21	91.5 ± 37	12 ±
Cisplatin	7.5	Ondansetron	2	143.8 ± 80	47.3 ± 41	5.3 ± 5a
Apomorphine	1.6	NS		39.4 ± 36	28.5 ± 16	5.3 ± 1.9
Apomorphine	1.6	Metoclopramide	4	-a	1.3 ± 3b	0.3 ± 0.8d

^aP = 0.018, t = 2.93 vs vehicle-pretreated cisplatin group; ^bP = 0.0022, t’ = 4.08, ^dP = 0.003, t’ = 5.94 vs vehicle-pretreated apomorphine group; -a: only 1 monk had retching and vomiting.