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©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Feb 28, 2006; 12(8): 1235-1242
Published online Feb 28, 2006. doi: 10.3748/wjg.v12.i8.1235
Published online Feb 28, 2006. doi: 10.3748/wjg.v12.i8.1235
Table 1 Main characteristics of Crohn’s disease in non-appendectomized and appendectomized patients
Non-appendectomized | Appendectomized | P | |
Number of patients | 1770 | 716 | |
Female gender | 1019 (58) | 515 (72) | 0.001 |
Age at diagnosis (yr) | 27.5 ± 12.8 | 32.1 ± 13 | 0.001 |
Duration of disease (yr)1 | 9.6 ± 8.6 | 9.1 ± 8.1 | NS |
Caucasian ethnicity | 1484 (84) | 663 (93) | 0.001 |
High socio-economic status | 535 (30) | 171 (24) | 0.001 |
Disease onset after 1987 | 1374 (78) | 554 (77) | NS |
Familial history | 272 (15) | 79 (11) | 0.004 |
Current smokers | 856 (48) | 444 (62) | 0.001 |
Disease location | |||
Terminal ileum (L1) | 489 (28) | 277 (39) | |
Colon (L2) | 548 (31) | 173 (24) | 0.001 |
Ileocolon (L3) | 514 (29) | 187 (26) | |
Upper gastrointestine (L4) | 219 (12) | 79 (11) | |
Extra-intestinal manifestations | 1136 (64) | 422 (59) | 0.01 |
Table 2 5-yr and 10-yr cumulative risks of intestinal and perianal complications in non-appendectomized and appendectomized patients according to disease location
Non-appendectomized | Appendectomized | ||||||||
Location | L1 | L2 | L3 | L4 | L1 | L2 | L3 | L4 | |
Number of patients | 493 | 546 | 513 | 218 | 279 | 172 | 186 | 79 | |
Intestinal stricture | 5-yr | 23 ± 2 | 2 ± 1 | 9 ± 1 | 22 ± 3 | 30 ± 3 b | 3 ± 2 | 12 ± 3 | 29 ± 6 |
10-yr | 34 ± 3 | 7 ± 1 | 17 ± 2 | 42 ± 5 | 46 ± 4 b | 6 ± 2 | 24 ± 4 | 42 ± 7 | |
Intestinal perforation | 5-yr | 30 ± 2 | 7 ± 1 | 12 ± 2 | 12 ± 2 | 27 ± 3 | 4 ± 2 a | 13 ± 3 | 10 ± 4 |
10-yr | 42 ± 3 | 12 ± 2 | 25 ± 2 | 23 ± 4 | 37 ± 4 | 4 ± 2 a | 23 ± 4 | 29 ± 7 | |
Perianal fistulization | 5-yr | 14 ± 2 | 32 ± 2 | 31 ± 2 | 23 ± 3 | 11 ± 2 | 19 ± 3 b | 26 ± 4 | 15 ± 4 |
10-yr | 18 ± 2 | 49 ± 3 | 41 ± 3 | 29 ± 4 | 17 ± 3 | 33 ± 5 b | 40 ± 5 | 21 ± 6 |
Table 3 Cumulative therapeutic needs in non-appendectomized and appendectomized patients according to disease location
Non-appendectomized | Appendectomized | |||||||
Location | L1 | L2 | L3 | L4 | L1 | L2 | L3 | L4 |
Number of patients | 493 | 546 | 513 | 218 | 279 | 172 | 186 | 79 |
Oral or IV steroids | 396 (80) | 469 (86) | 462 (90) | 195 (89) | 228 (82) | 150 (87) | 173 (93) | 71 (90) |
Enteral or parenteral nutrition | 53 (11) | 1 | 94 (18) | 48 (22) | 23 (8) | 0 | 35 (19) | 13 (16) |
Azathioprine or methotrexate | 163 (33) | 305 (56) | 290 (57) | 132 (61) | 100 (36) | 83 (48) | 101 (54) | 48 (61) |
Infliximab | 9 (2) | 73 (13) | 48 (9) | 19 (9) | 4 (1) | 11 (6) | 14 (8) | 5 (6) |
Intestinal resection | 283 (57) | 173 (32) | 176 (34) | 79 (36) | 165 (59) | 42 (24) | 73 (39) | 30 (38) |
Table 4 Comparison between two groups of patients included in prospective follow-up study
Non-appendectomized | Appendectomized | |
Number of patients | 591 | 591 |
Number of females | 427 | 427 |
Mean age at diagnosis (yr) | 31.8 ± 13.8 | 32.3 ± 13.4 |
Mean age at inclusion (yr) | 34.0 ± 13.9 | 34.8 ± 13.7 |
Diagnosis after 1987 (n) | 539 | 524 |
Diagnosis after 1995 (n) | 351 | 357 |
L1 location (n) | 202 | 204 |
L2 location (n) | 162 | 160 |
L3 location (n) | 156 | 156 |
L4 location (n) | 71 | 71 |
- Citation: Cosnes J, Seksik P, Nion-Larmurier I, Beaugerie L, Gendre JP. Prior appendectomy and the phenotype and course of Crohn’s disease. World J Gastroenterol 2006; 12(8): 1235-1242
- URL: https://www.wjgnet.com/1007-9327/full/v12/i8/1235.htm
- DOI: https://dx.doi.org/10.3748/wjg.v12.i8.1235