Down-expression of tumor protein p53-induced nuclear protein 1 in human gastric cancer

Table 1 TP53INP1 expression in gastric cancer n (%)

		Non-malignant gastric tissue (n=142)	Gastric cancer(n=142)1	P value
TP53INP1	Positive	139 (98)	91 (64)	<0.0001
	Negative	3 (2)	51 (36)
P53	Positive	0 (0)	68 (47.9)	<0.0001
	Negative	142 (100)	74 (52.1)

¹In gastric cancer the P value between TP53INP1 and P53 was 0.006.

Table 2 Correlation between TP53INP1 expression levels and clinicopathologic features in gastric cancer

	TP53INP1-positive(n=91 of 142 patients)	TP53INP1-negative (n=51 of 142 patients)	P value
Age (years)
<60	31	18	NS
≥60	60	33
Sex
Male	68	36	NS
Female	23	15
Location
Cardia	20	22
Body	58	26	0.0193
Antrum	13	3
Histological type
Differentiateda	62	14
Undifferentiatedb	29	37	<0.0001
Tumor invasion
T1a+T1b	23	4	0.0111
T2+T3+T4	68	47
Lymph node metastasis
Positive	5	11	0.0037
Negative	86	40
Liver metastasis
Positive	0	5	0.0024
Negative	91	46
Lymphatic invasion
Positive	50	42	0.0010
Negative	41	9

NS: not significant.

^aDifferentiated type corresponds to well and moderately differentiated tubular and papillar tumors (intestinal type).

^bUndifferentiated type includes poorly differentiated and signet-ring cell carcinomas (diffuse type).

Table 3 Multivariate survival analysis using the Cox regression model

Factor	Reference	Odds Ratio	p
TP53INP1	+ vs -	1.250	0.3680
Age	<60 vs≥60	1.388	0.1077
Gender	Male vs female	1.158	0.5217
Location	Body+cardia vs antrum	1.253	0.4847
Histological type	Poor vs well+moderately	2.043	0.0026
Tumor invasion	T2+T3+T4 vs T1	1.061	0.8485
Stage	III+IV vs II+I	1.269	0.2612
Apoptotic index	≤4% vs >4%	2.244	0.0008
Metastasis	+ vs -	18.688	0.0007
Lymphatic invasion	+ vs -	0.721	0.2124
Lymph node invasion	+ vs -	3.121	0.0032