Non invasive evaluation of liver fibrosis in paediatric patients with nonalcoholic steatohepatitis

Table 1 Anthropometric, clinical and biochemical characteristics

Variables characteristics	mean ± SD	Range
Age (mo)	145.7 ± 39.5	44-226
BMI (kg/m2)	26.3 ± 4.1	15.2-38.3
BMI Z score	2.0 ± 0.79	0.8-5.0
Type II diabetes n (%)	2 (2.3)
Hypertension n (%)	2 (2.3)
AST (IU/L)	42 ± 16	19-90
ALT (IU/L)	60 ± 31	10-192
GT (IU/L)	23 ± 20	10-130
Cholesterol (mg/dL)	152 ± 32	75-222
Triglyceride (mg/dL)	86 ± 44.5	28-348
Fasting glucose (mg/dL)	82 ± 11	60-138
Fasting insulin (mU/L)	12.5 ± 6.4	3.5-30.7
HOMA-IR	2.55 ± 1.39	0.67-6.29
ISI-comp	4.4 ± 2.0	1.26-9.16

of patients (n = 69) BMI: body mass index; AST: aspartate aminotransferase; ALT: alanine Aminotransferase; γGT: gamma-glutamyl transpeptidase; HOMA-IR: homeostatic model assessment-insulin resistence; ISI: insulin sensitivity index.

Table 2 Histological findings in the patients population (Biopsies scored according to Kleiner et al), n (%)

Grade/Stage	Steatosis	Necroinflammation	Fibrosis
0	-	12 (17.4)	28 (40.6)
1	25 (36.2)	52 (75.3)	36 (52.2)
2	27 (39.2)	5 (7.2)	1 (1.4)
3	17 (24.6)	-	4 (5.8)
4	-	-	-

Table 3 Comparison of clinical and biochemical features according to stage of fibrosis (mean ± SD)

Features	No fibrosis	Fibrosis≥1	P
n (%)	28 (40.6)	41 (59.4)
Age (mo)	140.3 ± 34	151.4 ± 41	0.2
Fasting glucose (mg/dL)	82.4 ± 9.9	81.5 ± 11.7	0.7
BMI (kg/m2)	25.2 ± 3.3	27.5 ± 4.5	0.01
BMI-SDS	1.84 ± 0.5	2.0 ± 0.7	0.05
Cholesterol (mg/dL)	148.8 ± 34.4	160.2 ± 36.2	0.2
Triglycerides (mg/dL)	82.4 ± 59.5	97.9 ± 39.4	0.2
Systolic pressure (mmHg)	110.2 ± 11.6	116 ± 15	0.07
Diastolic pressure (mmHg)	67.0 ± 8.2	67.1 ± 8.3	0.9
AST (U/L)	41.6 ± 14.6	49.3 ± 32.2	0.18
ALT (U/L)	65.6 ± 26	76.2 ± 82.6	0.4
AST/ALT	0.7 ± 0.3	0.9 ± 0.5	0.05
GT (U/L)	25.2 ± 25	23.7 ± 16.6	0.7
PLT (103/L)	285 ± 66	295 ± 59	0.5
PT	87.9 ± 9.3	90.2 ± 7.6	0.3
HOMA-IR	2.7 ± 1.5	2.4 ± 1.1	0.4
ISI	4.0 ± 1.7	4.5 ± 1.9	0.4
Fasting insulin (mU/L)	13.5 ± 6.7	11.6 ± 5.8	0.2

BMI-SDS: body mass index standard deviation score; AST: aspartate aminotransferase; ALT: alanine aminotransferase; PLT: platelets count; PT: prothrombin time; HOMA-IR: homeostatic model assessment-insulin resistence; ISI: insulin sensitivity index.