An algorithm for family screening for coeliac disease

Table 1 Sensitivity, specificity and reproducibility of screening coeliac serology

	IgA-AGA	IgG-AGA	IgA-EMA
Sensitivity	83	86	90
Specificity	82	76	99

Table 2 Overall results of coeliac screening for singly and multiply affected families

Type of family	Coeliacs	Relatives	Positive	1st degree	2nd degree	Not
	(n)	(n)	screenings	relatives	relatives	related
Singly affected family	73	223	11	11	0	0
Multiply affected family	232	691	28	22	2	4

Table 3 Single affected families-relationships of individuals to probands

Relationship	Numbertested (n)	Numberaffected (n)	Percentageaffected (%)
Mother	73	5	6.85
Father	73	4	5.48
Sibling	37	2	5.41
Child	18	0	0
Uncle/Aunt	5	0	0
Grandparent	6	0	0
Grandchild	2	0	0
Nephew/Niece	3	0	0
Husband/Wife	6	0	0

Table 4 Mutliply affected Families-Relationships of Individuals to probands

Relationship	Numbertested (n)	Numberaffected (n)	Percentageaffected (%)
Mother	51	3	5.88
Father	31	3	9.68
Sibling	165	9	5.4
Child	137	7	5.11
Uncle/Aunt	6	1	16.67
Grandparent	11	0	0
Grandchild	39	0	0
Nephew/Niece	67	1	1.49
3rd degree or more	24	0	0
Husband/Wife	159	4	2.52

Table 5 Results of HLA-typing for individuals with positive screening tests

HLA-type	DR3/DRx	DR3/DR7	DR5/DR7	DR4	DR3/DR4	DR4/DR7
Number	25	4	0	0	0	0
Percentage	86.2%	13.8%	0	0	0	0