Brain edema and intracranial hypertension in fulminant hepatic failure: Pathophysiology and management

Table 1 Liver transplantation criteria in patients with fulminant hepatic failure

Clichy criteria (Hepatology 1991; 14: 49A)

Grade III or IV encephalopathy and

- Factor V level < 20% (patients younger than 30)

- Factor V level < 30% (patients older than 30)

King’s College criteria (Modified from Gastroenterology 1989; 97: 439-445)

Paracetamol intoxication:

- pH < 7.3 or

- INR > 4 and serum creatinin > 300 μmol/L (> 34 mg/L) and grade

III or IV encephalopathy

Other causes:

- INR > 4 or

- 3 of the following criteria:

- Age < 10 or > 40 yr

- Etiology: NonA nonB hepatitis, halothane hepatitis, idiosyncratic drug reactions

- Delay between jaundice and encephalopathy > 7 d

- INR > 3.5

- Bilirubin > 300 μmol/L (> 175 mg/L)