H Pylori
Copyright ©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Dec 7, 2006; 12(45): 7278-7284
Published online Dec 7, 2006. doi: 10.3748/wjg.v12.i45.7278
Table 1 Characteristics of the 79 patients at the time of inclusion
CharacteristicsGroup 1(Hepatitis)Group 2(Cirrhosis)Group 3(Controls)
Patients (n)411226
Age (yr)50 ± 1360 ± 11a49 ± 12
Gender (M/F)14/275/713/13
Route of transmission, n (%)
Transfusion10 (24%)5 (42%)-
IVDU11 (27%)3 (25%)-
Other or unknow20 (49%)4 (33%)-
Duration of infection (yr)19 ± 923 ± 5-
Alcohol intake (g/d)12 ± 2312 ± 14-
AST (xULN)1.5 ± 1.13.7 ± 2.4b-
ALT (xULN)1.7 ± 1.33.7 ± 2.8b-
GGT (xULN)1.4 ± 0.72.0 ± 1.9-
HCV genotype, n (%)-
124 (58%)8 (67%)-
2/311 (27%)4 (33%)-
Other6 (15%)0 (0%)-
HCV viral load (IU/mL)827 889 ± 123 741923 026 ± 181 866-
Histological lesions (Metavir)
Activity, n (%)
A0-116 (39%)0 (0%)-
A2-325 (61%)12 (100%)a-
Fibrosis, n (%)
F0-116 (39%)--
F223 (56%)--
F32 (5%)--
F4-12 (100%)-
Table 2 Factors associated with Helicobacter DNA presence in the liver
FactorHelicobacter DNA
P
PresentAbsent
Patients (n)1241
Age (yr)46 ± 1354 ± 130.05
Gender (M/F)5/712/29NS
Route of transmission
Transfusion3 (25%)12 (29%)
IVDU3 (25%)11 (27%)NS
Other or unknown6 (50%)18 (44%)
Duration of infection (yr) (n = 36)18 ± 721 ± 8NS
Alcohol intake (g/d)5 ± 814 ± 24NS
AST (xULN)2.2 ± 2.11.9 ± 1.5NS
ALT (xULN)2.7 ± 2.92.0 ± 1.5NS
GGT (xULN)1.3 ± 0.51.6 ± 1.2NS
HCV genotype
19 (75%)23 (56%)
2/32 (17%)13 (24%)NS
Other1 (8%)5 (20%)
HCV viral load (IU/mL)663 824 ± 569 933972 157 ± 1 388 853NS
Histological lesions (Metavir score)
Activity
A0-14 (33%)12 (29%)
A2-38 (67%)29 (71%)NS
Fibrosis
F0-27 (58%)32 (78%)
F3-45 (42%)9 (22%)NS
Table 3 Results of H pylori serology, urea breath test (UBT) and species identification in the liver, for the 16 patients positive for Helicobacter genus-specific PCR in the liver
GroupsPatient No.H pylori infection
H pylori PCR
H. pullorum PCR
Conclusion
SerologyUBT23S rDNAureA26 kDaglmMcdtB
Group 11-------Not identified
(Hepatitis)2----+-+H. pullorum”-like1
3--+++--H pylori”-like1
4++++---H pylori”-like
5+++++--H pylori”-like1
6-------Not identified
7--+----H pylori”-like1
Group 28--+++--H pylori”-like1
(Cirrhosis)9--++++-H pylori”-like1
10ND-++++-H pylori”-like
11----+--H pylori”-like
12+---+-+H. pullorum”-like
Group 313----+--H pylori”-like
(Controls)14----+--H pylori”-like1
15+ND-++--H pylori”-like
16--+++--H pylori”-like

  • Citation: Castéra L, Pedeboscq A, Rocha M, Bail BL, Asencio C, Lédinghen V, Bernard PH, Laurent C, Lafon ME, Capdepont M, Couzigou P, Bioulac-Sage P, Balabaud C, Mégraud F, Ménard A. Relationship between the severity of hepatitis C virus-related liver disease and the presence of Helicobacter species in the liver: A prospective study. World J Gastroenterol 2006; 12(45): 7278-7284
  • URL: https://www.wjgnet.com/1007-9327/full/v12/i45/7278.htm
  • DOI: https://dx.doi.org/10.3748/wjg.v12.i45.7278