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©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Dec 7, 2006; 12(45): 7278-7284
Published online Dec 7, 2006. doi: 10.3748/wjg.v12.i45.7278
Published online Dec 7, 2006. doi: 10.3748/wjg.v12.i45.7278
Characteristics | Group 1(Hepatitis) | Group 2(Cirrhosis) | Group 3(Controls) |
Patients (n) | 41 | 12 | 26 |
Age (yr) | 50 ± 13 | 60 ± 11a | 49 ± 12 |
Gender (M/F) | 14/27 | 5/7 | 13/13 |
Route of transmission, n (%) | |||
Transfusion | 10 (24%) | 5 (42%) | - |
IVDU | 11 (27%) | 3 (25%) | - |
Other or unknow | 20 (49%) | 4 (33%) | - |
Duration of infection (yr) | 19 ± 9 | 23 ± 5 | - |
Alcohol intake (g/d) | 12 ± 23 | 12 ± 14 | - |
AST (xULN) | 1.5 ± 1.1 | 3.7 ± 2.4b | - |
ALT (xULN) | 1.7 ± 1.3 | 3.7 ± 2.8b | - |
GGT (xULN) | 1.4 ± 0.7 | 2.0 ± 1.9 | - |
HCV genotype, n (%) | - | ||
1 | 24 (58%) | 8 (67%) | - |
2/3 | 11 (27%) | 4 (33%) | - |
Other | 6 (15%) | 0 (0%) | - |
HCV viral load (IU/mL) | 827 889 ± 123 741 | 923 026 ± 181 866 | - |
Histological lesions (Metavir) | |||
Activity, n (%) | |||
A0-1 | 16 (39%) | 0 (0%) | - |
A2-3 | 25 (61%) | 12 (100%)a | - |
Fibrosis, n (%) | |||
F0-1 | 16 (39%) | - | - |
F2 | 23 (56%) | - | - |
F3 | 2 (5%) | - | - |
F4 | - | 12 (100%) | - |
Factor | Helicobacter DNA | P | |
Present | Absent | ||
Patients (n) | 12 | 41 | |
Age (yr) | 46 ± 13 | 54 ± 13 | 0.05 |
Gender (M/F) | 5/7 | 12/29 | NS |
Route of transmission | |||
Transfusion | 3 (25%) | 12 (29%) | |
IVDU | 3 (25%) | 11 (27%) | NS |
Other or unknown | 6 (50%) | 18 (44%) | |
Duration of infection (yr) (n = 36) | 18 ± 7 | 21 ± 8 | NS |
Alcohol intake (g/d) | 5 ± 8 | 14 ± 24 | NS |
AST (xULN) | 2.2 ± 2.1 | 1.9 ± 1.5 | NS |
ALT (xULN) | 2.7 ± 2.9 | 2.0 ± 1.5 | NS |
GGT (xULN) | 1.3 ± 0.5 | 1.6 ± 1.2 | NS |
HCV genotype | |||
1 | 9 (75%) | 23 (56%) | |
2/3 | 2 (17%) | 13 (24%) | NS |
Other | 1 (8%) | 5 (20%) | |
HCV viral load (IU/mL) | 663 824 ± 569 933 | 972 157 ± 1 388 853 | NS |
Histological lesions (Metavir score) | |||
Activity | |||
A0-1 | 4 (33%) | 12 (29%) | |
A2-3 | 8 (67%) | 29 (71%) | NS |
Fibrosis | |||
F0-2 | 7 (58%) | 32 (78%) | |
F3-4 | 5 (42%) | 9 (22%) | NS |
Groups | Patient No. | H pylori infection | H pylori PCR | H. pullorum PCR | Conclusion | ||||
Serology | UBT | 23S rDNA | ureA | 26 kDa | glmM | cdtB | |||
Group 1 | 1 | - | - | - | - | - | - | - | Not identified |
(Hepatitis) | 2 | - | - | - | - | + | - | + | “H. pullorum”-like1 |
3 | - | - | + | + | + | - | - | “H pylori”-like1 | |
4 | + | + | + | + | - | - | - | “H pylori”-like | |
5 | + | + | + | + | + | - | - | “H pylori”-like1 | |
6 | - | - | - | - | - | - | - | Not identified | |
7 | - | - | + | - | - | - | - | “H pylori”-like1 | |
Group 2 | 8 | - | - | + | + | + | - | - | “H pylori”-like1 |
(Cirrhosis) | 9 | - | - | + | + | + | + | - | “H pylori”-like1 |
10 | ND | - | + | + | + | + | - | “H pylori”-like | |
11 | - | - | - | - | + | - | - | “H pylori”-like | |
12 | + | - | - | - | + | - | + | “H. pullorum”-like | |
Group 3 | 13 | - | - | - | - | + | - | - | “H pylori”-like |
(Controls) | 14 | - | - | - | - | + | - | - | “H pylori”-like1 |
15 | + | ND | - | + | + | - | - | “H pylori”-like | |
16 | - | - | + | + | + | - | - | “H pylori”-like |
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Citation: Castéra L, Pedeboscq A, Rocha M, Bail BL, Asencio C, Lédinghen V, Bernard PH, Laurent C, Lafon ME, Capdepont M, Couzigou P, Bioulac-Sage P, Balabaud C, Mégraud F, Ménard A. Relationship between the severity of hepatitis C virus-related liver disease and the presence of
Helicobacter species in the liver: A prospective study. World J Gastroenterol 2006; 12(45): 7278-7284 - URL: https://www.wjgnet.com/1007-9327/full/v12/i45/7278.htm
- DOI: https://dx.doi.org/10.3748/wjg.v12.i45.7278