Expression of altered retinoblastoma protein inversely correlates with tumor invasion in gastric carcinoma

Table 1 Altered pRb expression and clinicopathological findings in 91 patients with gastric adenocarcinoma

Variables	n	Altered pRb expression, n (%)		P
		Strong	Weak
Age
< 70 yr	43	7 (16)	36 (84)	0.307
≥ 70 yr	48	12 (25)	36 (75)
Sex
Male	80	17 (21)	63 (79)	1.000
Female	11	2 (18)	9 (82)
Tumor location
Upper third	18	2 (11)	16 (89)	0.553
Middle third	19	5 (26)	14 (74)
Lower third	54	12 (22)	42 (78)
Lauren type
Intestinal	67	12 (18)	55 (82)	0.304
Diffuse	20	4 (20)	16 (80)
Mixed	4	2 (50)	2 (50)
Differentiation
High or moderately	49	10 (20)	39 (80)	0.905
Low	42	9 (21)	33 (79)
Tumor depth
T1	17	6 (35)	11 (65)	0.047
T2	21	5 (24)	16 (76)
T3	46	8 (17)	38 (83)
T4	7	0 (0)	7 (100)
Lymph node metastasis
N0	28	9 (32)	19 (68)	0.109
N1	35	6 (17)	29 (83)
N2	22	3 (14)	19 (86)
N3	6	1 (17)	5 (83)
Distant metastasis
No	75	17 (23)	58 (77)	0.366
Yes	16	2 (13)	14 (87)
TNM stage
Iand II	43	14 (33)	29 (67)	0.010
III and IV	48	5 (10)	43 (90)

Table 2 Univariate analysis of survival in 75 patients with curative resection for gastric adenocarcinoma

Variables	5-year survival, n (%)	P
Age
< 70 yr	36 (54.0)	0.8036
≥ 70 yr	39 (58.8)
Sex
Male	69 (57.2)	0.5069
Female	6 (50.0)
Tumor location
Upper third	14 (51.9)	0.4312
Middle third	14 (64.8)
Lower third	47 (54.6)
Differentiation
Well + moderate	41 (66.1)	0.0509
Low	34 (42.5)
TNM stage
Iand II	43 (88.6)	< 0.0001
III and IV	32 (14.7)
Altered pRb expression
strong	17 (80.5)	0.0436
weak	58 (49.6)

Table 3 Multivariate analysis of survival in 75 patients wirh curative resection for gastric adenocarcinoma

Variables	Category	Relative risk	95% CI	P
Histologic grade	Poorly vs well and moderately- differentiated	1.073	0.640-1.800	0.788
Altered pRB expression	Weak vs strong	0.891	0.443-1.791	0.746
TNM stages	III & IV vsI& II	5.067	2.764-9.289	0.000