Rapid Communication
Copyright ©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Nov 28, 2006; 12(44): 7172-7178
Published online Nov 28, 2006. doi: 10.3748/wjg.v12.i44.7172
Table 1 Correlation between the serum levels of pepsinogen and gastrin with the type and topography of histological gastritis (median)
Chronic non-atrophicgastritis (n = 10)Antrum-predominant atrophicgastritis (n = 10)Corpus-predominantatrophic gastritis1 (n = 9)
PG-1 (µg/L)a115.6103.340.9
PG-1/PG-2a4.395.622.22
17-gastrinb (pmol/L)6.23.736.8
Table 2 Diagnostic performance of serology (pepsinogen and 17-gastrin) to diagnose gastric atrophy
Cut-off levelSensitivity% (95% CI)Specificity% (95% CI)LR5+LR-Youden’s J index
PG-1 (µg/L)3< 25144 (12-77)95 (87-100)8.80.590.40 ± 0.17
≤ 61.5278 (40-97)91 (71-99)8.60.240.69 ± 0.15
PG-1/PG-23< 2.5156 (21-86)100 (84-100)0.440.56 ± 0.17
≤ 2.22
17-gastrin (pmol/L)< 21430 (16-58)86 (70-100)2.10.810.16 ± 0.16
≤ 7.52490 (56-98)52 (30-74)1.890.190.42 ± 0.14
> 13.32367 (30-92)96 (77-99)14.70.350.62 ± 0.16
Table 3 Characteristics of the asymptomatic population samples according to the estimated gastric cancer risk
CharacteristicsEstimated gastric cancer risk
Total(n = 536)
Low (A)(n = 115)Medium (B)(n = 354)High (C)(n = 67)
Corpus atrophy1AbsentAbsentPresent
H pylori infection2AbsentPresentPresent or absent
Men, n (%)46 (40.0)168 (47.5)35 (52.2)249 (46.5)
Age (yr)a, (mean ± SD)49.6 ± 22.248.6 ± 18.061.9 ± 13.350.5 ± 19.0
Educational level (yr)a, (mean ± SD)8.8 ± 5.28.2 ± 4.35.8 ± 4.28.0 ± 4.6
Rurality, n (%)27 (23.5)99 (28.0)22 (32.8)148 (27.6)
Living in high-risk counties, n (%)39 (33.9)146 (41.2)24 (35.8)209 (39.0)
17-Gastrina (pmol/L), (mean ± SD)4.1 ± 6.85.6 ± 7.114 ± 14.36.3 ± 8.8