Hyperbilirubinemia after extracorporeal circulation surgery: A recent and prospective study

Table 1 Comparison of perioperative changes of liver function in two groups (mean ± SD)

Variable	HB group				NHB group
	Preop	d1	d2	d7	Preop	d1	d2	d7
TB (mmol/L)	26.8 ± 2.6d	72.7 ± 9.1bd	82.8 ± 10.4bd	63.8 ± 7.5bd	14.5 ± 1.4	33.8 ± 5.5b	20.8 ± 4.5	17.1 ± 3.7
UCB (mmol/L)	9.9 ± 1.9	47.6 ± 6.5b	40.9 ± 6.7bd	32.6 ± 5.6bd	6.5 ± 1.7	18.6 ± 3.9b	11.9 ± 3.2	9.7 ± 1.9
CB (mmol/L)	16.7 ± 1.5d	24.7 ± 5.1bd	39.6 ± 6.1bd	31.2 ± 5.4bd	8.4 ± 1.3	15.5 ± 3.1b	9.4 ± 2.1	7.6 ± 1.6
ALT (IU/L)	40.6 ± 3.9d	112.6 ± 11.6bd	176 ± 15.6bd	56.6 ± 5.5d	28.5 ± 2.6	84.6 ± 11.6d	60.6 ± 5.7	50.2 ± 5.1
AST (IU/L)	40.5 ± 3.6	102.6 ± 10.7d	184 ± 17.1bd	53.2 ± 5.2d	42.6 ± 3.3	80.5 ± 10.5d	55.1 ± 5.5	48.3 ± 4.9

Preop: Preoperative; d1, d2, d7: first, second, and seventh postoperative days, respectively.

^bP < 0.01 versus Preop:

^dP < 0.01 HB group versus NHB group at the same time point.

Table 2 Comparison of mortality, ventilation time and ICU stay time in two groups (mean ± SD)

Variable	HB group	NHB group	P value
Mortality	4.10%	0.3%b	P < 0.01
Ventilation time (h)	25.5 ± 13.3	16.5 ± 9.2a	P < 0.05
ICU stay time (d)	11.5 ± 6.5	4.1 ± 3.9a	P < 0.05

^bP < 0.01 vs HB group;

^aP < 0.05 vs HB group.

Table 3 Analysis of possible risk factors for the postoperative hyperbilirubinemia (mean ±  SD)

Possible risk factors	HB group	NHB group	P
Age (yr)	47 ± 1.16	46. ± 1.02	> 0.25
Body surface area (m2)	1.66 ± 0.01	1.63 ± 0.03	> 0.10
Preoperative TB (μmol/L)	26.8 ± 2.6	14.5 ± 2.3	< 0.01
Preoperative CB (μmol/L)	16.7 ± 1.4	8.4 ± 1.5	< 0.01
Preoperative TB/CB	1.69 ± 0.01	1.71 ± 0.02	> 0.30
Preoperative ALT (IU/L)	40.6 ± 3.9	28.5 ± 2.6	< 0.05
Preoperative AST (IU/L)	40.5 ± 3.6	42.6 ± 3.3	> 0.10
Right atrial pressure (mmHg)	9.5 ± 0.6	4.9 ± 0.5	< 0.01
Pulmonary artery pressure (mmHg)	35.5 ± 1.5	23.5 ± 1.3	< 0.01
Blood transfusion requirement (u)	3.56 ± 0.02	2.15 ± 0.03	< 0.01
Operation time (min)	220.5 ± 6.0	205.5 ± 5.3	> 0.15
CPB time (min)	130.3 ± 4.2	112.2 ± 3.1	< 0.01
Aortic crossclamp time (min)	76.6 ± 3.1	68.6 ± 2.3	< 0.01
Lowest nasopharyngeal temperature (°C)	26.7 ± 0.4	26.3 ± 0.3	> 0.25
Lowest MAP (mmHg)	68.6 ± 1.3	65.9 ± 1.5	> 0.15
Lowest PO2 (mmHg)	66.6 ± 1.4	68.7 ± 1.5	> 0.20

Table 4 Results of logistic regression for the risk factors of postoperative hyperbilirubinemia

Variable	β	SE	Significance	R
Preoperative TB	1.274	0.312	0.000	0.205
Right atrial pressure	0.113	0.032	0.006	0.147
Number of valves replaced	0.658	0.302	0.025	0.152
Blood transfusion requirement (u)	0.109	0.033	0.006	0.118
Constant	-3.453	0.466	0.000

β: Regression coefficient; SE: Standard error; R: Partial correlation coefficient.