Basic Research
Copyright ©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Nov 7, 2006; 12(41): 6639-6645
Published online Nov 7, 2006. doi: 10.3748/wjg.v12.i41.6639
Table 1 General characteristics of rats
CharacteristicsSham
BDL
P
Placebo n = 9V-PYRRO/NO n = 12Placebo n = 12V-PYRRO/NO n = 10
Initial body weight (g)299 ± 34 274 ± 29288 ± 56 293 ± 67NS
Body weight gain (%)33 ± 2122 ± 9 14 ± 12a21 ± 170.04
Liver / body weight (%)2.3 ± 0.4 2.8 ± 0.3 5.9 ± 1.5a5.6 ± 2.0c< 0.0001
Ascites score00 0.3 ± 0.90NS
Table 2 Liver and kidney serum function tests of rats
ParameterSham
BDL
P
Placebo n = 9V-PYRRO/NO n = 12Placebo n = 12V-PYRRO/NO n = 10
Urea (mmol/L)10.2 ± 2.17.9 ± 1.79.2 ± 1.69.5 ± 2.7NS
Creatinine (μmol/L)77 ± 2563 ± 2466 ± 1173 ± 18NS
AST (UI/L)172 ± 52123 ± 601150 ± 1480a1164 ± 1349c< 0.0001
ALT (UI/L)48 ± 1855 ± 3688 ± 4782 ± 20NS
Alkaline phosphatases (UI/L)160 ± 103148 ± 80380 ± 197a367 ± 141c< 0.001
Bilirubin (μmol/L)1.0 ± 0.01.3 ± 0.5117.0 ± 22.0a101.0 ± 30.0c< 0.0001
Table 3 Hemodynamic data of rats
Sham
BDL
P
Placebo n = 9V-PYRRO/NO n = 12Placebo n = 12V-PYRRO/NO n = 10
MAP (mm Hg)119 ± 7113 ± 11104 ± 8a98 ± 13b< 0.001
Heart rate (beat/min)441 ± 29428 ± 44411 ± 29422 ± 26NS
Cardiac index (mL/min .100 g)14 ± 515 ± 439 ± 11a33 ± 6ac< 0.0001
SVR (dyn.s.cm5.100 g1.103)782 ± 355636 ± 184236 ± 89a248 ± 78c< 0.0001
Portal pressure (mmHg)9.2 ± 0.88.0 ± 1.216.3 ± 2.2a11.9 ± 2.7ace< 0.0001
SRS BF (mL/min)0.22 ± 0.080.31 ± 0.121.33 ± 1.34a0.42 ± 0.22e0.007
Table 4 Liver fibrosis of rats
Sham
BDL
P
Placebo n = 9V-PYRRO/NO n = 12Placebo n = 12V-PYRRO/NO n = 10
Area (%)2.5 ± 0.53.1 ± 0.812.1 ± 4.3a8.4 ± 3.6ce< 0.0001
Liver hydroxyproline (μg/g protein)164 ± 26171 ± 49381 ± 88a268 ± 83ce< 0.0001