Role of gastric oxidative stress and nitric oxide in formation of hemorrhagic erosion in rats with ischemic brain

doi:10.3748/wjg.v12.i4.574

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Jan 28, 2006 (publication date) through Feb 2, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 28, 2006; 12(4): 574-581
Published online Jan 28, 2006. doi: 10.3748/wjg.v12.i4.574

Table 1 Influences of gastric juice on various gastric biomedical parameters in sham operation and BCAL rats

	Acid back-diffusion(μEq/stomach)	Glutathione(μmol/gtissue)	Lipid peroxide(nmol MDA/gtissue)	Hemoglobin(mg/stomach)	Erosion(areamm²)	Histologicalscore
Sham operation
Saline	56.0 ± 6.0	3.0 ± 0.4	36.1 ± 4.5	0.1 ± 0.1	0.3 ± 0.2	0.3 ± 0.1
Gastric juice	-135.6 ± 4.4	2.6 ± 0.3	50.1 ± 6.4	0.3 ± 0.1	0.4 ± 0.8	0.7 ± 0.3
BCAL
Saline	30.2 ± 4.1^a	2.1 ± 0.3^a	88.1 ± 3.4^a	0.8 ± 0.2^a	8.2 ± 0.9^a	1.8 ± 0.3^a
Gastric juice	-250.2 ± 10.4^c	1.4 ± 0.2 ^c	137.6 ± 10.4^c	2.0 ± 0.4^c	40.2 ± 7.1^c	4.5 ± 0.7^c

Data are means±SE (N = 8). Significant differences are analyzed by using ANOVA.

^aP < 0.05 vs saline treated sham operation group;

^cP < 0.05 vs gastric juice treated sham operation group, BCAL= bilateral carotid artery ligation, MDA = malonedialdehyde.

Table 2 Effects of allopurinol or exogenous glutathione on various gastric parameters in sham operation and BCAL rats

	mg/kg	Acid back-diffusion (μEq/stomach)	Glutathione (μmol/g tissue)	Lipid peroxide (nmol MDA/g tissue)	Histamine (μg/g tissue)	Hemoglobin (mg/stomach)	Erosion area (mm²)
Sham operation
Vehicle		-135.4 ± 4.4	2.8 ± 0.3	50.1 ± 4.5	56.1 ± 5.4	0.5 ± 0.2	2.4 ± 3.5
Allopurinol	100	-112.0 ± 3.8^a	3.0 ± 0.3	40.2 ± 4.7^a	40.5 ± 5.1^a	0.2 ± 0.1^a	0.2 ± 0.2^a
Glutathione	800	-98.0 ± 2.4^a	3.4 ± 0.2^a	36.1 ± 2.5^a	38.1 ± 4.6^a	0.1 ± 0.1^a	0.4 ± 0.2^a
BCAL
Vehicle		-250.2 ± 14.4	1.4 ± 0.2	128.0 ± 9.3	120.4 ± 9.8	2.3 ± 0.3	45.2 ± 6.1
Allopurinol	100	-181.5 ± 5.8^c	2.2 ± 0.2^c	68.4 ± 5.1^c	77.3 ± 6.9^c	1.2 ± 0.2^c	20.3 ± 2.9^c
Glutathione	800	-146.0 ± 3.4^c	2.7 ± 0.2^c	56.1 ± 4.5^c	80.1 ± 4.6^c	0.1 ± 0.1^c	12.4 ± 3.5^c

Data are means±SE (N = 6).

^aP < 0.05 vs sham operative vehicle.

^cP < 0.05 vs BCAL vehicle. MDA= malonedialdehyde, BCAL= bilateral carotid artery ligation.

Table 3 Effect of L-NAME on L-arginine produced amelioration of various gastric biomedical parameters in sham operation and BCAL rats

	mg/kg	Acid back-diffusion(μEq/stomach)	Glutathione(μmol/g tissue)	Lipid peroxides(nmol MDA/g tissue)	Histamine(μg/g stomach)	Hemoglobin(mg/stomach)	Erosionarea (mm²)
Sham operation
Vehicle		-125.2 ± 4.4	2.6 ± 0.3	48.1 ± 3.4	52.8 ± 4.6	0.1 ± 0.1	3.2 ± 0.7
L-arginine	500	-96.0 ± 6.0^a	3.5 ± 0.4^a	36.1 ± 4.5^a	38.2 ± 3.6^a	0 ± 0^a	0.3 ± 0.2^a
L-NAME25
+ L-arginine	500	-156.0 ± 11.0^a^c	2.3 ± 0.2^c	60.1 ± 4.5^a^c	72.4 ± 6.3^a^c	0.7 ± 0.1^a^c	12.0 ± 3.5^a^c
BCAL
Vehicle		-245.2 ± 14.4	1.6 ± 0.2	127.8 ± 9.3	110.4 ± 9.8	1.6 ± 0.3	36.2 ± 5.1
L-arginine
	25	-216.1 ± 9.6^a	2.0 ± 0.2	80.8 ± 7.8^a	98.7 ± 10.4	1.3 ± 0.2	28.2 ± 5.4
	250	-189.4 ± 3.6^a	2.3 ± 0.3^a	66.7 ± 4.4^a	84.3 ± 7.4^a	1.0 ± 0.1^a	20.0 ± 4.8^a
	500	-144.0 ± 11.0^a	2.6 ± 0.2^a	46.1 ± 8.5^a	54.1 ± 8.6^a	0.7 ± 0.1^a	12.0 ± 3.5^a
L-NAME	25
+ L-arginine	500	-287.6 ± 16.4^a^c	1.2 ± 0.2^a^c	157.6 ± 11.3^a^c	110.4 ± 9.8^a^c	2.8 ± 0.3^a^c	56.2 ± 6.0^a^c

Data are means±SE (N = 6).

^aP < 0.05 vs corresponding vehicle.

^cP< 0.05 vs corresponding arginine treatment (500 mg/kg) of BCAL group. MDA= malonedialdehyde, BCAL= bilateral carotid artery ligation, L-NAME= NG-nitro-L-arginine-methyl ester.

Citation: Hung CR. Role of gastric oxidative stress and nitric oxide in formation of hemorrhagic erosion in rats with ischemic brain. World J Gastroenterol 2006; 12(4): 574-581
URL: https://www.wjgnet.com/1007-9327/full/v12/i4/574.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i4.574