Aberrant cytological localization of p16 and CDK4 in colorectal epithelia in the normal adenoma carcinoma sequence

Table 1 Relationship between the subcellular expression pattern of p16 or CDK4 and the histology of epithelia of normal-adenoma-carcinoma sequence

	Subcellular expression pattern
Histology	Total	C/N	C
p16
Normal	42	40	2
Adenoma	43	32	11
Carcinoma	73	27	46
P < 0.001
CDK4
Normal	38	29	9
Adenoma	43	10	33
Carcinoma	74	15	59
P < 0.001

C/N: Cytoplasm/nucleus.

Table 2 Relationship between p16 subcellular expression pattern and clinicopathological features

	p16 subcellular pattern
Clinicopathological feature	n	C/N	C
Dukes’ stage
A	22	8	14
B	22	6	16
C	29	13	16
Histological grade
I	24	8	16
II	40	16	24
III	9	3	6
Total	73	27	46

C/N: Cytoplasm/nucleus. There was no significant correlation between p16 subcellular expression pattern and the Dukes’ stage (P = 0.441) or histological grade (P = 0.865) of the carcinoma.

Table 3 Relationship between CDK4 subcellular expression pattern and clinicopathological features

	CDK4 subcellular pattern
Clinicopathological feature	n	C/N	C
Dukes’ stage
A	22	4	18
B	22	4	18
C	30	7	23
Histological grade
I	24	4	20
II	41	10	31
III	9	1	8
Total	74	15	59

C/N: cytoplasm/nucleus. There was no significant correlation between CDK4 subcellular expression pattern and the Dukes’ stage (P = 0.844) or histological grade (P = 0.584) of the carcinoma.