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©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Oct 21, 2006; 12(39): 6325-6330
Published online Oct 21, 2006. doi: 10.3748/wjg.v12.i39.6325
Published online Oct 21, 2006. doi: 10.3748/wjg.v12.i39.6325
Table 1 Characteristics of patients with ulcerative colitis
Characteristic | UC (n = 131) |
Age of onset (yr) | 36.8 ± 15.3 |
Colitis duration (yr) | 8.8 ± 7.7 |
Extension | |
Proctitis | 22 (16.8%) |
Left-sided | 59 (45.0%) |
Pancolitis | 50 (38.2%) |
Type of clinical course | |
First episode | 14 (10.7%) |
Chronic relapse | 79 (60.3%) |
Chronic persistent | 38 (29.0%) |
Severity | |
Mild | 40 (30.5%) |
Moderate | 61 (46.6%) |
Severe | 30 (22.9%) |
Table 2 Allele frequency and genotype distribution of LPL polymorphism in UC patients and controls
Allele frequency | Genotype (%) | OR (95% CI) | |||
Ser447stop | C | G | CC | CG+GG | |
UC (n = 131) | 0.92 | 0.08 | 111 (84.7) | 19 + 1 (15.3) | 1.49 |
Control (n = 104) | 0.88 | 0.12 | 82 (78.8) | 19 + 3 (21.2) | (0.76-2.91) |
HindIII | H+ | H- | H+/+ | H+/- + H-/- | |
UC (n = 130) | 0.80 | 0.20 | 86 (66.1) | 37 + 7 (33.9) | 1.28 |
Control (n = 106) | 0.74 | 0.26 | 64 (60.4) | 28 + 14 (39.6) | (0.75-2.18) |
PvuII | P+ | P- | P+/+ | P+/- + P-/- | |
UC (n = 131) | 0.70 | 0.30 | 65 (49.6) | 53 + 13 (50.4) | 1.44 |
Control (n = 106) | 0.64 | 0.36 | 43 (40.6) | 50 + 13 (59.4) | (0.86-2.42) |
Table 3 Age of onset of UC patients and LPL polymorphisms
Age of onset (yr) | Genotype | OR (95% CI) | |
Ser447stop | C/G+G/G | C/C | |
< 20 (n = 15) | 5 | 10 | 3.13 |
≥ 20 (n = 116) | 16 | 100 | (0.94-10.33) |
HindIII | H+/- + H-/- | H+/+ | |
< 20 (n = 15) | 8 | 7 | 2.31 |
≥ 20 (n = 115) | 36 | 79 | (0.84-7.45) |
PvuII | P+/- + P-/- | P+/+ | |
< 20 (n = 15) | 9 | 6 | 1.55 |
≥ 20 (n = 116) | 57 | 59 | (0.52-4.64) |
Table 4 Triglyceride levels of UC patients and LPL polymorphisms
- Citation: Kosaka T, Yoshino J, Inui K, Wakabayashi T, Okushima K, Kobayashi T, Miyoshi H, Nakamura Y, Hayashi S, Shiraishi T, Watanabe M, Yamamoto T, Nakahara A, Katoh T. Impact of lipoprotein lipase gene polymorphisms on ulcerative colitis. World J Gastroenterol 2006; 12(39): 6325-6330
- URL: https://www.wjgnet.com/1007-9327/full/v12/i39/6325.htm
- DOI: https://dx.doi.org/10.3748/wjg.v12.i39.6325