Basic Research
Copyright ©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Oct 21, 2006; 12(39): 6325-6330
Published online Oct 21, 2006. doi: 10.3748/wjg.v12.i39.6325
Table 1 Characteristics of patients with ulcerative colitis
CharacteristicUC (n = 131)
Age of onset (yr)36.8 ± 15.3
Colitis duration (yr)8.8 ± 7.7
Extension
Proctitis22 (16.8%)
Left-sided59 (45.0%)
Pancolitis50 (38.2%)
Type of clinical course
First episode14 (10.7%)
Chronic relapse79 (60.3%)
Chronic persistent38 (29.0%)
Severity
Mild40 (30.5%)
Moderate61 (46.6%)
Severe30 (22.9%)
Table 2 Allele frequency and genotype distribution of LPL polymorphism in UC patients and controls
Allele frequencyGenotype (%)OR (95% CI)
Ser447stopCGCCCG+GG
UC (n = 131)0.920.08111 (84.7)19 + 1 (15.3)1.49
Control (n = 104)0.880.1282 (78.8)19 + 3 (21.2)(0.76-2.91)
HindIIIH+H-H+/+H+/- + H-/-
UC (n = 130)0.800.2086 (66.1)37 + 7 (33.9)1.28
Control (n = 106)0.740.2664 (60.4)28 + 14 (39.6)(0.75-2.18)
PvuIIP+P-P+/+P+/- + P-/-
UC (n = 131)0.700.3065 (49.6)53 + 13 (50.4)1.44
Control (n = 106)0.640.3643 (40.6)50 + 13 (59.4)(0.86-2.42)
Table 3 Age of onset of UC patients and LPL polymorphisms
Age of onset (yr)GenotypeOR (95% CI)
Ser447stopC/G+G/GC/C
< 20 (n = 15)5103.13
≥ 20 (n = 116)16100(0.94-10.33)
HindIIIH+/- + H-/-H+/+
< 20 (n = 15)872.31
≥ 20 (n = 115)3679(0.84-7.45)
PvuIIP+/- + P-/-P+/+
< 20 (n = 15)961.55
≥ 20 (n = 116)5759(0.52-4.64)
Table 4 Triglyceride levels of UC patients and LPL polymorphisms
Triglycerides(mg/dL)GenotypeOR (95%CI)
Ser447stopC/CC/G + G/G
≥ 150 (n = 20)1914.93 (0.61-40.03)
< 150 (n = 68)5414
HindIIIH+/+H+/- + H-/-
≥ 150 (n = 20)18b26.46 (1.39-30.12)
< 150 (n = 67)3928
PvuIIP+/+P+/- + P-/-
≥ 150 (n = 20)13a73.0 (1.06-8.50)
< 150 (n = 68)2642