Copyright
©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Oct 21, 2006; 12(39): 6325-6330
Published online Oct 21, 2006. doi: 10.3748/wjg.v12.i39.6325
Published online Oct 21, 2006. doi: 10.3748/wjg.v12.i39.6325
Characteristic | UC (n = 131) |
Age of onset (yr) | 36.8 ± 15.3 |
Colitis duration (yr) | 8.8 ± 7.7 |
Extension | |
Proctitis | 22 (16.8%) |
Left-sided | 59 (45.0%) |
Pancolitis | 50 (38.2%) |
Type of clinical course | |
First episode | 14 (10.7%) |
Chronic relapse | 79 (60.3%) |
Chronic persistent | 38 (29.0%) |
Severity | |
Mild | 40 (30.5%) |
Moderate | 61 (46.6%) |
Severe | 30 (22.9%) |
Allele frequency | Genotype (%) | OR (95% CI) | |||
Ser447stop | C | G | CC | CG+GG | |
UC (n = 131) | 0.92 | 0.08 | 111 (84.7) | 19 + 1 (15.3) | 1.49 |
Control (n = 104) | 0.88 | 0.12 | 82 (78.8) | 19 + 3 (21.2) | (0.76-2.91) |
HindIII | H+ | H- | H+/+ | H+/- + H-/- | |
UC (n = 130) | 0.80 | 0.20 | 86 (66.1) | 37 + 7 (33.9) | 1.28 |
Control (n = 106) | 0.74 | 0.26 | 64 (60.4) | 28 + 14 (39.6) | (0.75-2.18) |
PvuII | P+ | P- | P+/+ | P+/- + P-/- | |
UC (n = 131) | 0.70 | 0.30 | 65 (49.6) | 53 + 13 (50.4) | 1.44 |
Control (n = 106) | 0.64 | 0.36 | 43 (40.6) | 50 + 13 (59.4) | (0.86-2.42) |
Age of onset (yr) | Genotype | OR (95% CI) | |
Ser447stop | C/G+G/G | C/C | |
< 20 (n = 15) | 5 | 10 | 3.13 |
≥ 20 (n = 116) | 16 | 100 | (0.94-10.33) |
HindIII | H+/- + H-/- | H+/+ | |
< 20 (n = 15) | 8 | 7 | 2.31 |
≥ 20 (n = 115) | 36 | 79 | (0.84-7.45) |
PvuII | P+/- + P-/- | P+/+ | |
< 20 (n = 15) | 9 | 6 | 1.55 |
≥ 20 (n = 116) | 57 | 59 | (0.52-4.64) |
- Citation: Kosaka T, Yoshino J, Inui K, Wakabayashi T, Okushima K, Kobayashi T, Miyoshi H, Nakamura Y, Hayashi S, Shiraishi T, Watanabe M, Yamamoto T, Nakahara A, Katoh T. Impact of lipoprotein lipase gene polymorphisms on ulcerative colitis. World J Gastroenterol 2006; 12(39): 6325-6330
- URL: https://www.wjgnet.com/1007-9327/full/v12/i39/6325.htm
- DOI: https://dx.doi.org/10.3748/wjg.v12.i39.6325