Cytoplasmic expression of p27kip1 is associated with a favourable prognosis in colorectal cancer patients

Table 1 Patient and tumor characteristics (n = 462)

Variable	Category	n (%)
Age (yr)	Median Range	72 57-89
Gender	Male Female	266 (58) 196 (42)
Status	Alive Dead (cancer related) Dead (unrelated causes) Unknown	169 (37) 228 (49) 64 (14) 1
Histological type	Adenocarcinoma Adenocarcinoma with Mucinous differentiation Adenocarcinoma with Signet ring differentiation Other Unknown	392 (85) 51 (11) 7 (1) 4 (1) 8 (2)
Histological grade	Well differentiated Moderately differentiated Poorly differentiated Unknown	29 (6) 353 (77) 71 (15) 9 (2)
Tumor site	Colon Rectal Unknown	238 (52) 181 (39) 43 (9)
TNM stage	0 (Tis) 1 2 3 4 Unknown	3 (1) 69 (15) 174 (38) 155 (33) 54 (12) 7 (2)
Extramural vascular invasion	Negative Positive Unknown	224 (48) 128 (28) 110 (24)

Table 2 p27^kip1 localisation within 418 colorectal tumor specimens

p27 localisation	Positive n (%)	Negative n (%)	Missing n (%)
Nuclear	217 (51.9)	201 (48.1)	44 (9.5)
Cytoplasmic	79 (18.9)	339 (81.1)	44 (9.5)

Table 3 Multivariate analysis of Cytoplasmic p27^kip expression in relation to known clinical and pathological variables (n = 418)

Variable	Category	Hazardratio(HR)	95% CIfor HR	P
Gender	Female	1
	Male	1.055	0.787-1.415	0.719
Patient age (yr)	< 65	1
	65-79	1.262	0.843-1.889
	80+	1.609	0.961-2.694	0.194
Tumor site	Colon	1
	Rectal	1.117	0.813-1.535
	Unknown	1.452	0.870-2.423	0.353
Tumor histological type	Adenocarcinoma	1
	Non-adenocarcinoma	0.956	0.621-1.472	0.838
Tumor grade	Well differentiated	1
	Moderately differentiated	1.167	0.582-2.337
	Poorly differentiated	1.139	0.528-2.457
	Unknown	0.869	0.245-3.079	0.926
Vascular invasion	Negative	1
	Positive	1.884	1.344-2.641
	Unknown	1.308	0.876-1.954	0.001
Tumor (TNM) stage	0/I	1
	II	2.021	1.102-3.708
	III	3.741	2.066-6.774
	IV	16.977	8.829-32.645
	Unknown	4.211	1.049-16.902	< 0.001
Cytoplasmic p27Kip1 expression	Negative	1
	Positive	0.681	0.458-1.015	0.059