Human papillomavirus in esophageal squamous cell carcinoma in Colombia and Chile

Table 1 Clinico-pathological distribution of ESCC cases in Colombia and Chile

	Colombia (%)	Chile (%)	P
Age (yr)	63.6 ± 12.9	72.2 ± 8.9	0.003
Sex			1.000
Female	22 (47)	12 (46)
Male	25 (53)	14 (54)
Differentiation of tumors			0.071
Well	17 (36)	4 (15)
Moderate	23 (49)	13 (50)
Poor	7 (15)	9 (35)
p16 expression1			0.625
Negative	21 (46)	14 (54)
Positive2	25 (54)	12 (46)

¹p16 expression was not examined in 1 Colombian case because of inappropriate condition for immunostaining;

²Positive p16 expression: p16 immunostaning was observed in 10% or higher of observed carcinoma cells.

Table 2 HPV detection in 73 cases of Colombia and Chile ESCC

	n	HPV16 (%)	P	HPV18 (%)	p
Country			0.506		0.011
Colombia	47	6 (13)		10 (21)
Chile	26	5 (19)		0 (0)
Sex			0.745		0.499
Female	34	6 (18)		6 (18)
Male	39	5 (13)		4 (10)
Age (yr)			0.316		0.212
< 60	19	1 (5)		5 (26)
60-	22	3 (14)		2 (9)
70-	32	7 (22)		3 (9)
Differentiation of tumors			0.834		0.682
Well	21	4 (19)		4 (19)
Moderate	36	5 (14)		4 (11)
Poor	16	2 (13)		2 (13)
p16 expression			0.190		0.515
Negative	35	3 (9)		6 (17)
Positive1	37	8 (22)		4 (11)

¹Positive p16 expression: p16 immunostaning was observed in 10% or higher of observed carcinoma cells.