Total plasma homocysteine and methylenetetrahydrofolate reductase C677T polymorphism in patients with colorectal carcinoma

doi:10.3748/wjg.v12.i38.6128

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Oct 14, 2006 (publication date) through Oct 30, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Colorectal Cancer

World J Gastroenterol. Oct 14, 2006; 12(38): 6128-6132
Published online Oct 14, 2006. doi: 10.3748/wjg.v12.i38.6128

Table 1 Characteristics of control subjects and cancer patients

Group	Sex (M/F)	Mean age ± SD (yr)(range)	TNM staging
Controls	100 (56/44)	64 ± 6 (46-79)	//
Cancer patients	93 (51/42)	62 ± 8 (48-78)	T_1-3, N_0-2, M₀

Full Size Table

Table 2 tHcy plasma levels according to C677T MTHFR polymorphism [mean ± SD (μmol/L) (n)]

Group (n)	CC genotype	CT genotype	TT genotype
Control subjects (100)	9.01 ± 2.76 (30)	9.71 ± 2.34 (51)	17.56 ± 10.81^d^f (19)
Cancer patients (93)	11.82 ± 3.09^a (32)	12.45 ± 4.46^b (40)	16.88 ± 9.25 ^d^f (21)

^aP < 0.05,

^bP < 0.01 vs control;

^dP < 0.01 TT vs CC;

^fP < 0.01 TT vs CT.

Full Size Table

Table 3 tHcy plasma levels according to CC + CT genotype of C677T MTHFR polymorphism [mean ± SD (μmol/L) (n)]

Group	(CC+CT) genotype
Control subjects	9.45 ± 2.51 (81)
Cancer patients	12.17 ± 3.90^b (72)

^bP < 0.002 vs control.

Full Size Table

Citation: Battistelli S, Vittoria A, Stefanoni M, Bing C, Roviello F. Total plasma homocysteine and methylenetetrahydrofolate reductase C677T polymorphism in patients with colorectal carcinoma. World J Gastroenterol 2006; 12(38): 6128-6132
URL: https://www.wjgnet.com/1007-9327/full/v12/i38/6128.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i38.6128