Expression of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in ulcerative colitis

Table 1 Expression of MMP-1 mRNA in samples form different areas of colon in UC (mean±SD)

Samples	MMP-1 mRNA	P value
Ulcerated area	0.4136 ± 0.2495	< 0.001bd
Inflamed area	0.1491 ± 0.0891	< 0.001bd < 0.05a
Non-inflamed area	0.0102 ± 0.0144	> 0.05
Normal controls	0.0051 ± 0.0086

^bP < 0.001 vs normal controls,

^dP < 0.001 vs non-inflamed area,

^aP < 0.05 vs ulcerated area.

Table 2 Expression of TIMP-1 mRNA in samples from different areas of colon in UC (mean±SD)

Samples	TIMP-1	P value
Ulcerated area	0.8512 ± 0.4169	< 0.001bd
Inflamed area	0.7493 ± 0.3505	< 0.05ace
Non-inflamed area	0.4434 ± 0.3360	> 0.05
Normal control	0.3903 ± 0.2971

^bP < 0.001 vs normal controls,

^dP < 0.001 vs non-inflamed area,

^aP < 0.05 vs normal controls,

^cP < 0.05 vs non-inflamed area,

^eP < 0.05 vs ulcerated area.

Table 3 Positive expression rates of MMP-1 in samples from different areas of colon in UC

Samples	Positive cases	Negative cases	Total cases	Positive rate (%)	P Value
Ulcerated area	25	5	30	87	< 0.05ac
Inflamed area	25	5	30	87	< 0.05ac
Non-inflamed area	12	18	30	40	> 0.05
Normal controls	7	13	20	35

^aP < 0.05 vs normal controls,

^cP < 0.05 vs non-inflamed area.

Table 4 Intensity of MMP-1 expression in samples from different areas of colon in UC

Sampes	-	+	++	+++	P value
Ulcerated area	5	2	4	19	< 0.001ac
Inflamed area	5	5	16	4	< 0.05ace
Non-inflamed area	18	10	2	0	> 0.05
Normal controls	13	6	1	0

^aP < 0.05 vs normal controls,

^cP < 0.05 vs non-inflamed area,

^eP < 0.05 vs ulcerated area.

Table 5 Positive expression rates of TIMP-1 in samples of different areas of colon in UC

Samples	Positive cases	Negative cases	Total cases	Positive rate (%)	P value
Ulcerated area	26	4	30	89	> 0.05
Inflamed area	26	4	30	89	> 0.05
Non-inflamed area	24	6	30	80	> 0.05
Normal controls	15	5	20	75

Table 6 Intensity of TIMP-1 expression in samples from different areas of colon in UC

Samples	-	+	++	+++	P value
Ulcerated area	4	7	9	10	< 0.05ac
Inflamed area	4	8	13	5	< 0.05ace
Non-inflamed area	6	19	5	0	> 0.05
Normal controls	5	11	4	0

^aP < 0.05 vs normal controls,

^cP < 0.05 vs non-inflamed area,

^eP < 0.05 vs ulcerated area.