Reduced expression of Ca2+-regulating proteins in the upper gastrointestinal tract of patients with achalasia

doi:10.3748/wjg.v12.i37.6002

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Oct 7, 2006 (publication date) through Feb 11, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical Research

World J Gastroenterol. Oct 7, 2006; 12(37): 6002-6007
Published online Oct 7, 2006. doi: 10.3748/wjg.v12.i37.6002

Table 1 Ratios of CRT/CSQ and CRT/SERCA 2b in esophageal body (EB) and lower esophageal sphincter (LES) and LES pressure of achalasia patients and healthy controls (mean ± SE)

	EB		LES
	Control (n = 6)	Achalasia(n = 9)	Control(n = 6)	Achalasia(n = 9)
Pressure (mm Hg)	ND	ND	31.2 ± 2.9	49.2 ± 3.8^a
CRT/CSQ	0.63 ± 0.08	0.61 ± 0.04	0.88 ± 0.10	0.78 ± 0.08
CRT/SERCA 2b	1.07 ± 0.20	0.77 ± 0.10	1.47 ± 0.09	1.07 ± 0.08^a

CRT: Calreticulin; CSQ: Calsequestrin; SERCA: Sarcoplasmic reticulum Ca²⁺ ATPase; ND: Not done.

^aP < 0.05 vs controls.

Citation: Fischer H, Fischer J, Boknik P, Gergs U, Schmitz W, Domschke W, Konturek JW, Neumann J. Reduced expression of Ca²⁺-regulating proteins in the upper gastrointestinal tract of patients with achalasia. World J Gastroenterol 2006; 12(37): 6002-6007
URL: https://www.wjgnet.com/1007-9327/full/v12/i37/6002.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i37.6002