Expression pattern of leptin and leptin receptor (OB-R) in human gastric cancer

Table 1 Relationship between expression of Ob-R and leptin

	Ob-R expression
	Positive (67)	Negative (140)	P
Leptin expression
Strong (74)	45	29
Weak (133)	22	111	< 0.001

Table 2 Expression of leptin and clinicopathologic characteristics of patients

	Leptin expression			OB-R expression
	High (74)	Low (133)	P	Positive (67)	Negative (140)	P
Age (yr)	62.7 ± 8.9	61.3 ± 11.2	0.98	64.2 ± 9.9	61.6 ± 10.8	0.167
Sex
Male	64	91		53	102
Female	10	42	0.003	14	38	0.33
BMI	22.4 ± 3.1	22.7 ± 2.8	0.48	22.4 ± 3.2	22.7 ± 2.8	0.49
Tumor markers
CEA	8.6 ± 17.7	14.7 ± 111.3	0.65	9.9 ± 19.6	13.8 ± 108.3	0.79
CA19-9	89.8 ± 453.5	75.4 ± 347.6	0.81	138.3 ± 561.4	53.8 ± 270.8	0.16
Size (cm)	6.0 ± 3.2	5.1 ± 3.6	0.13	5.8 ± 3.2	5.2 ± 3.6	0.25
Location
Upper part (51)	23	28		19	32
Middle part (94)	36	58		29	65
Lower part (62)	15	47	0.03	19	43	0.51
Depth of tumor invasion
T1	24	76		20	80
T2	28	29		27	37
T3	18	28		16	30
T4	4	0	0.001	4	0	< 0.001
Macroscopic type
Elevated	57	62		48	71
Depressed/flat	17	71	< 0.001	19	69	0.005
Histological type
Differentiated	45	43		43	45
Undifferentiated	29	90	< 0.001	24	95	< 0.001
TNM stage
IA	20	67		15	72
IB	17	23		15	25
II	8	12		9	11
IIIA	10	17		11	16
IIIB	5	7		7	5
IV	14	7	0.001	10	11	< 0.001
Lymphatic invasion
Positive	39	45		39	46
Negative	34	87	0.002	28	94	< 0.001
Venous invasion
Positive	46	49		45	50
Negative	28	84	< 0.001	22	90	< 0.001
Lymph node metastasis
Positive	47	48		48	47
Negative	37	85	0.052	19	93	0.001
Hematogenous metastasis
Positive	3	0		2	1
Negative	71	134	0.02	65	139	0.19
Peritoneal dissemination
Positive	5	1		2	4
Negative	69	133	0.01	65	136	0.95