Genetic association of autoimmune hepatitis and human leucocyte antigen in German patients

Table 1 Most prevalent HLA subtypes in German patients with autoimmune hepatitis type 1

HLA	AIH type IGerman patients
C7	90 (63%)
A2	68 (48%)
B8	63 (44%)
DR3	49 (38%)
DR4	49 (38%)
DQ2	42 (41%)

Table 2 Prevalence of HLA subtypes in German patients with autoimmune hepatitis type 1 and comparison to worldwide populations

HLA	Germany	Italy5	N. America5	N. America II8	UK6	West India10	Japan7	China9	Brazil8	Turkey11
	n = 142	n = 57	n = 149	n = 161	n = 87	n = 20	n = 77	n = 32	n = 115	n = 17
A2	48%					16%
B8	45%	32%	49%			3%
C7	63%	51%			70%	29%
DR3	38%	30%	52%	47%		11%	31%	16%	32%	17%
DR4	38%	23%	43%	45%		3%	83%	50%	16%	59%
DR7	16%	16%	15%
DR11	13%	18%	7%
DR13	13%	26%	16%
DQ2	41%	53%	57%
B8-DR3-DQ2	27%	30%	48%

Table 3 Most prevalent HLA subtypes in German patients with SLA/LP positive autoimmune hepatitis

HLA	AIH SLA/LP positiveGerman patientsn = 29
A2	16 (55%)
B8	15 (52%)
C7	22 (76%)
DR3	12 (41%)
DQ2	13 (45%)