Gastric cancer in a Caucasian population: Role of pepsinogen C genetic variants

Table 1 Allelic distribution of PGC polymorphism according to the type of gastric lesion or its absence n (%)

	Allele 1carrier	Allele 2 carrier	Allele 3/4 carrier	Allele 5 carrier	Allele 6 carrier
Controls (n = 127)	2 (1.6)	31 (24.4)	39 (30.7)	37 (19.1)	92 (72.4)
All cases (n = 99)	1 (1.0)	30 (30.3)	33 (33.3)	39 (39.4)	47 (47.5)
AIM (n = 42)	-	16 (38.1)	14 (33.3)	16 (38.1)	18 (42.9)
GC (n = 57)	1 (1.8)	14 (24.6)	19 (33.3)	23 (40.4)	29 (50.9)

AIM: Atrophy or intestinal metaplasia; GC: Gastric adenocarcinoma.

Table 2 Association of PGC Allele 6 carriers and risk for development of associated lesions and invasive gastric adenocarcinoma

	Allele 6 carrier	P	OR	95% CI
	n (%)
Controls (n = 127)	92 (72.4)		1.00	Reference
All cases (n = 99)	47 (47.5)	< 0.001	0.34	0.20-0.60
AIM (n = 42)	18 (42.9)	< 0.001	0.28	0.14-0.59
GC (n = 57)	29 (50.9)	0.004	0.39	0.21-0.75

AIM: Atrophy or intestinal metaplasia; GC: Gastric adenocarcinoma; P: Pearson Chi-Square; OR: Odds ratio; CI: Confidence interval.

Table 3 Frequencies of PGC Allele 6 carriers within populations

	Population	n	Allele 6 Carriersn (%)
Our Study	Caucasian (Porto, Portugal)	127	92 (72.4)
Ohtaki et al, 1997	Asian (Fukui, Japan)	177	82 (46.3)
Liu et al, 2003	Asian (Shenyang, China)	42	24 (57.1)
	Asian (Zhuanghe, China)	113	69 (61.0)