Comparison between empirical prokinetics, Helicobacter test-and-treat and empirical endoscopy in primary-care patients presenting with dyspepsia: A one-year study

doi:10.3748/wjg.v12.i31.5010

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Aug 21, 2006 (publication date) through Feb 9, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical Research

World J Gastroenterol. Aug 21, 2006; 12(31): 5010-5016
Published online Aug 21, 2006. doi: 10.3748/wjg.v12.i31.5010

Table 1 Baseline characteristics

Group	Mean age	Sex (M/F)	Hpylori positive (%)	Mean baseline dyspepsia score
Empirical endoscopy (n = 83)	52.5 ± 13.2	25/58	37 (44.6%)	20.4 ± 4.0
H pylori test-and-treat (n = 78)	46.5 ± 14.2	24/54	41 (52.6%)	20.8 ± 3.8
Empirical prokinetics (n = 73)	48.6 ± 13.0	22/51	30 (41.1%)	19.6 ± 3.8
P value	0.01^a	0.99	0.35	0.16

^aP < 0.05.

Table 2 Endoscopic findings in the three groups n (%)

	Normal	Gastritis/	Gastric	Gastric	Duodenal	Oesop-
		duodenitis	erosions	ulcer	ulcer	hagitis
Empirical endoscopy (n = 83)	49 (59)	27 (32.5)	2 (2.4)	3 (3.6)	1 (1.2)	1 (1.2)
H pylori test-and- treat (n = 78)	61 (78.2)	10 (12.8)	4 (5.1)	0	3 (3.9)	0
Empirical prokinetics (n = 73)	46 (63.0)	17 (23.3)	4 (5.5)	3 (4.1)	3 (4.1)	0

Table 3 Mean dyspepsia symptom score by initial diagnosis

	Baseline	Wk 6	Yr 1
Non-ulcer dyspepsia (n = 210)¹	20.3	15.0	20.1
Duodenal Ulcer (n = 7)	19.1	13.0	13.7
Gastric ulcer (n = 6)	23.3	18.7	14.4
Oesopohagitis (n = 1)	17.0	12.0	17.0
Gastric erosion (n = 10)	29.0	15.0	12.0
All causes organic dyspepsia (n = 24)¹	20.5	15.1	16.3

¹P = 0.045 between the two groups with age and sex as covariables.

Table 4 Median SF-36 quality-of-life scores for the three diagnostic and treatment groups (wk 0/ wk 6/ one year). Transformed scores out of 100

	BP	GH	MH	PF	RE	RP	SF	VT
All groups	63/84/51	40/47/42	72/72/60	95/95/85	100/100/67	50/100/75	88/88/75	45/50/50
Empirical endoscopy	62/84/51	50/52/50	72/72/60	95/95/85	100/100/67	75/100/75	75/100/75	50/45/50
H pylori test-and-treat	62/84/51	40/45/36	68/72/60	95/95 80	67/100/33	50/100/75	75/88/63	45/45/45
Empirical Prokinetics	72/84/52	39/49/45	76/72/64	95/95/85	100/100/67	50/100/75	88/88/75	45/50/50

BP: bodily pain; GH: general health; MH: mental health; PF: physical functioning; RE: role-emotional; RP: role-physical; SF: social functioning; VT: vitality.

Table 5 Patient satisfaction and preference among the three diagnostic and treatment groups n (%)

	Very	Satisfied	Neutral	Dissatisfied	Prefer initial
	satisfied				endoscopy
Empirical Endoscopy (n = 83)	7 (8.4)	59 (71)	14 (17)	3 (3.6)	63 (75.9)
H pylori test-and-treat (n = 78)	6 (7.7)	53 (67.9)	14 (17.9)	5 (6.4)	48 (61.5)
Empirical Prokinetics (n = 73)	6 (8.2)	56 (76.7)	8 (11.0)	3 (4.1)	43 (59.0)

Citation: Hu WH, Lam S, Lam CL, Wong W, Lam K, Lai K, Wong Y, Wong BC, Chan AO, Chan C, Leung GM, Hui W. Comparison between empirical prokinetics, Helicobacter test-and-treat and empirical endoscopy in primary-care patients presenting with dyspepsia: A one-year study. World J Gastroenterol 2006; 12(31): 5010-5016
URL: https://www.wjgnet.com/1007-9327/full/v12/i31/5010.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i31.5010